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2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.
Blomme A, Ford CA, Mui E, Patel R, Ntala C, Jamieson LE, Planque M, McGregor GH, Peixoto P, Hervouet E, Nixon C, Salji M, Gaughan L, Markert E, Repiscak P, Sumpton D, Blanco GR, Lilla S, Kamphorst JJ, Graham D, Faulds K, MacKay GM, Fendt SM, Zanivan S, Leung HY. Blomme A, et al. Nat Commun. 2020 May 19;11(1):2508. doi: 10.1038/s41467-020-16126-7. Nat Commun. 2020. PMID: 32427840 Free PMC article.
Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer.
Patel R, Brzezinska EA, Repiscak P, Ahmad I, Mui E, Gao M, Blomme A, Harle V, Tan EH, Malviya G, Mrowinska A, Loveridge CJ, Rushworth LK, Edwards J, Ntala C, Nixon C, Hedley A, Mackay G, Tardito S, Sansom OJ, Leung HY. Patel R, et al. Among authors: blomme a. Cancer Res. 2020 Feb 1;80(3):576-590. doi: 10.1158/0008-5472.CAN-19-1684. Epub 2019 Nov 12. Cancer Res. 2020. PMID: 31719098 Free article.
Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab.
Bellier J, Nokin MJ, Caprasse M, Tiamiou A, Blomme A, Scheijen JL, Koopmansch B, MacKay GM, Chiavarina B, Costanza B, Rademaker G, Durieux F, Agirman F, Maloujahmoum N, Cusumano PG, Lovinfosse P, Leung HY, Lambert F, Bours V, Schalkwijk CG, Hustinx R, Peulen O, Castronovo V, Bellahcène A. Bellier J, et al. Among authors: blomme a. Cell Rep. 2020 Feb 4;30(5):1400-1416.e6. doi: 10.1016/j.celrep.2020.01.012. Cell Rep. 2020. PMID: 32023458 Free article.
SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer.
Martinez RS, Salji MJ, Rushworth L, Ntala C, Rodriguez Blanco G, Hedley A, Clark W, Peixoto P, Hervouet E, Renaude E, Kung SHY, Galbraith LCA, Nixon C, Lilla S, MacKay GM, Fazli L, Gaughan L, Sumpton D, Gleave ME, Zanivan S, Blomme A, Leung HY. Martinez RS, et al. Among authors: blomme a. Cancer Res. 2021 Jul 1;81(13):3664-3678. doi: 10.1158/0008-5472.CAN-20-3694. Epub 2021 May 13. Cancer Res. 2021. PMID: 33985973 Free article.
Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis.
Ntala C, Salji M, Salmond J, Officer L, Teodosio AV, Blomme A, McGhee EJ, Powley I, Ahmad I, Kruithof-de Julio M, Thalmann G, Roberts E, Goodyear CS, Jamaspishvili T, Berman DM, Carlin LM, Le Quesne J, Leung HY. Ntala C, et al. Among authors: blomme a. Eur Urol Open Sci. 2021 May 25;29:19-29. doi: 10.1016/j.euros.2021.05.001. eCollection 2021 Jul. Eur Urol Open Sci. 2021. PMID: 34337530 Free PMC article.
THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer.
Blomme A, Peter C, Mui E, Rodriguez Blanco G, An N, Mason LM, Jamieson LE, McGregor GH, Lilla S, Ntala C, Patel R, Thiry M, Kung SHY, Leclercq M, Ford CA, Rushworth LK, McGarry DJ, Mason S, Repiscak P, Nixon C, Salji MJ, Markert E, MacKay GM, Kamphorst JJ, Graham D, Faulds K, Fazli L, Gleave ME, Avezov E, Edwards J, Yin H, Sumpton D, Blyth K, Close P, Murphy DJ, Zanivan S, Leung HY. Blomme A, et al. EMBO Mol Med. 2022 Mar 7;14(3):e14764. doi: 10.15252/emmm.202114764. Epub 2022 Jan 11. EMBO Mol Med. 2022. PMID: 35014179 Free PMC article.
Multi-omics & pathway analysis identify potential roles for tumor N-acetyl aspartate accumulation in murine models of castration-resistant prostate cancer.
Salji MJ, Blomme A, Däbritz JHM, Repiscak P, Lilla S, Patel R, Sumpton D, van den Broek NJF, Daly R, Zanivan S, Leung HY. Salji MJ, et al. Among authors: blomme a. iScience. 2022 Mar 11;25(4):104056. doi: 10.1016/j.isci.2022.104056. eCollection 2022 Apr 15. iScience. 2022. PMID: 35345457 Free PMC article.
Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer.
Almanza A, Mnich K, Blomme A, Robinson CM, Rodriguez-Blanco G, Kierszniowska S, McGrath EP, Le Gallo M, Pilalis E, Swinnen JV, Chatziioannou A, Chevet E, Gorman AM, Samali A. Almanza A, et al. Among authors: blomme a. Nat Commun. 2022 May 6;13(1):2493. doi: 10.1038/s41467-022-30159-0. Nat Commun. 2022. PMID: 35524156 Free PMC article.
Myoferlin is a key regulator of EGFR activity in breast cancer.
Turtoi A, Blomme A, Bellahcène A, Gilles C, Hennequière V, Peixoto P, Bianchi E, Noel A, De Pauw E, Lifrange E, Delvenne P, Castronovo V. Turtoi A, et al. Among authors: blomme a. Cancer Res. 2013 Sep 1;73(17):5438-48. doi: 10.1158/0008-5472.CAN-13-1142. Epub 2013 Jul 17. Cancer Res. 2013. PMID: 23864327 Free article.
49 results