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Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.
Dafinger C, Rinschen MM, Borgal L, Ehrenberg C, Basten SG, Franke M, Höhne M, Rauh M, Göbel H, Bloch W, Wunderlich FT, Peters DJM, Tasche D, Mishra T, Habbig S, Dötsch J, Müller RU, Brüning JC, Persigehl T, Giles RH, Benzing T, Schermer B, Liebau MC. Dafinger C, et al. Among authors: bloch w. Exp Mol Med. 2018 Jun 28;50(6):1-17. doi: 10.1038/s12276-018-0108-z. Exp Mol Med. 2018. PMID: 29959317 Free PMC article.
Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.
Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT. Ising C, et al. Among authors: bloch w. EMBO Mol Med. 2015 Mar;7(3):275-87. doi: 10.15252/emmm.201404916. EMBO Mol Med. 2015. PMID: 25643582 Free PMC article.
Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms.
Bultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A. Bultmann-Mellin I, et al. Among authors: bloch w. Dis Model Mech. 2015 Apr;8(4):403-15. doi: 10.1242/dmm.018960. Epub 2015 Feb 20. Dis Model Mech. 2015. PMID: 25713297 Free PMC article.
Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.
Ising C, Bharill P, Brinkkoetter S, Brähler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Höhne M, Müller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT. Ising C, et al. Among authors: bloch w. Am J Pathol. 2016 May;186(5):1128-39. doi: 10.1016/j.ajpath.2015.12.018. Am J Pathol. 2016. PMID: 27105734 Free article.
Maintaining proteostasis under mechanical stress.
Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B. Höhfeld J, et al. Among authors: bloch w. EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507. Epub 2021 Jul 26. EMBO Rep. 2021. PMID: 34309183 Free PMC article. Review.
Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier.
Koehler S, Odenthal J, Ludwig V, Unnersjö Jess D, Höhne M, Jüngst C, Grawe F, Helmstädter M, Janku JL, Bergmann C, Hoyer PF, Hagmann HH, Walz G, Bloch W, Niessen C, Schermer B, Wodarz A, Denholm B, Benzing T, Iden S, Brinkkoetter PT. Koehler S, et al. Among authors: bloch w. Kidney Int. 2022 Apr;101(4):733-751. doi: 10.1016/j.kint.2021.11.030. Epub 2021 Dec 17. Kidney Int. 2022. PMID: 34929254
709 results