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Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase.
Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. Ferrarone JR, et al. Among authors: blenis j. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2403685121. doi: 10.1073/pnas.2403685121. Epub 2024 May 14. Proc Natl Acad Sci U S A. 2024. PMID: 38743625 Free article.
The intrinsic substrate specificity of the human tyrosine kinome.
Yaron-Barir TM, Joughin BA, Huntsman EM, Kerelsky A, Cizin DM, Cohen BM, Regev A, Song J, Vasan N, Lin TY, Orozco JM, Schoenherr C, Sagum C, Bedford MT, Wynn RM, Tso SC, Chuang DT, Li L, Li SS, Creixell P, Krismer K, Takegami M, Lee H, Zhang B, Lu J, Cossentino I, Landry SD, Uduman M, Blenis J, Elemento O, Frame MC, Hornbeck PV, Cantley LC, Turk BE, Yaffe MB, Johnson JL. Yaron-Barir TM, et al. Among authors: blenis j. Nature. 2024 May 8. doi: 10.1038/s41586-024-07407-y. Online ahead of print. Nature. 2024. PMID: 38720073
LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase.
Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. Ferrarone JR, et al. Among authors: blenis j. bioRxiv [Preprint]. 2023 Oct 20:2023.10.19.563158. doi: 10.1101/2023.10.19.563158. bioRxiv. 2023. PMID: 37904985 Free PMC article. Preprint.
Balancing lysosome abundance in health and disease.
Mutvei AP, Nagiec MJ, Blenis J. Mutvei AP, et al. Among authors: blenis j. Nat Cell Biol. 2023 Sep;25(9):1254-1264. doi: 10.1038/s41556-023-01197-7. Epub 2023 Aug 14. Nat Cell Biol. 2023. PMID: 37580388 Review.
An atlas of substrate specificities for the human serine/threonine kinome.
Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andrée-Busch N, Käufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC. Johnson JL, et al. Among authors: blenis j. Nature. 2023 Jan;613(7945):759-766. doi: 10.1038/s41586-022-05575-3. Epub 2023 Jan 11. Nature. 2023. PMID: 36631611 Free PMC article.
245 results