Bleicher KH - Search Results

1

Ligand identification for G-protein-coupled receptors: a lead generation perspective.

Bleicher KH, Green LG, Martin RE, Rogers-Evans M. Bleicher KH, et al. Curr Opin Chem Biol. 2004 Jun;8(3):287-96. doi: 10.1016/j.cbpa.2004.04.008. Curr Opin Chem Biol. 2004. PMID: 15183327 Review.

2

Development of a virtual screening method for identification of "frequent hitters" in compound libraries.

Roche O, Schneider P, Zuegge J, Guba W, Kansy M, Alanine A, Bleicher K, Danel F, Gutknecht EM, Rogers-Evans M, Neidhart W, Stalder H, Dillon M, Sjögren E, Fotouhi N, Gillespie P, Goodnow R, Harris W, Jones P, Taniguchi M, Tsujii S, von der Saal W, Zimmermann G, Schneider G. Roche O, et al. J Med Chem. 2002 Jan 3;45(1):137-42. doi: 10.1021/jm010934d. J Med Chem. 2002. PMID: 11754585

3

Benzodioxoles: novel cannabinoid-1 receptor inverse agonists for the treatment of obesity.

Alig L, Alsenz J, Andjelkovic M, Bendels S, Bénardeau A, Bleicher K, Bourson A, David-Pierson P, Guba W, Hildbrand S, Kube D, Lübbers T, Mayweg AV, Narquizian R, Neidhart W, Nettekoven M, Plancher JM, Rocha C, Rogers-Evans M, Röver S, Schneider G, Taylor S, Waldmeier P. Alig L, et al. J Med Chem. 2008 Apr 10;51(7):2115-27. doi: 10.1021/jm701487t. Epub 2008 Mar 13. J Med Chem. 2008. PMID: 18335976

4

Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes.

Richter HG, Benson GM, Blum D, Chaput E, Feng S, Gardes C, Grether U, Hartman P, Kuhn B, Martin RE, Plancher JM, Rudolph MG, Schuler F, Taylor S, Bleicher KH. Richter HG, et al. Among authors: bleicher kh. Bioorg Med Chem Lett. 2011 Jan 1;21(1):191-4. doi: 10.1016/j.bmcl.2010.11.039. Epub 2010 Nov 12. Bioorg Med Chem Lett. 2011. PMID: 21134747

5

Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.

Feng S, Yang M, Zhang Z, Wang Z, Hong D, Richter H, Benson GM, Bleicher K, Grether U, Martin RE, Plancher JM, Kuhn B, Rudolph MG, Chen L. Feng S, et al. Bioorg Med Chem Lett. 2009 May 1;19(9):2595-8. doi: 10.1016/j.bmcl.2009.03.008. Epub 2009 Mar 9. Bioorg Med Chem Lett. 2009. PMID: 19328688

6

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties.

Richter HG, Benson GM, Bleicher KH, Blum D, Chaput E, Clemann N, Feng S, Gardes C, Grether U, Hartman P, Kuhn B, Martin RE, Plancher JM, Rudolph MG, Schuler F, Taylor S. Richter HG, et al. Among authors: bleicher kh. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1134-40. doi: 10.1016/j.bmcl.2010.12.123. Epub 2010 Dec 31. Bioorg Med Chem Lett. 2011. PMID: 21269824

7

Hit and lead generation: beyond high-throughput screening.

Bleicher KH, Böhm HJ, Müller K, Alanine AI. Bleicher KH, et al. Nat Rev Drug Discov. 2003 May;2(5):369-78. doi: 10.1038/nrd1086. Nat Rev Drug Discov. 2003. PMID: 12750740 Review.

8

Parallel solution- and solid-phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands.

Bleicher KH, Wüthrich Y, De Boni M, Kolczewski S, Hoffmann T, Sleight AJ. Bleicher KH, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2519-22. doi: 10.1016/s0960-894x(02)00488-2. Bioorg Med Chem Lett. 2002. PMID: 12182851

9

Parallel solution- and solid-phase synthesis of spiropyrrolo-pyrroles as novel neurokinin receptor ligands.

Bleicher KH, Wüthrich Y, Adam G, Hoffmann T, Sleight AJ. Bleicher KH, et al. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3073-6. doi: 10.1016/s0960-894x(02)00659-5. Bioorg Med Chem Lett. 2002. PMID: 12372504

10

Chemogenomics: bridging a drug discovery gap.

Bleicher KH. Bleicher KH. Curr Med Chem. 2002 Dec;9(23):2077-84. doi: 10.2174/0929867023368728. Curr Med Chem. 2002. PMID: 12470247 Review.

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