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92 results

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The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2.
Thompson KJ, Watson S, Zanato C, Dall'Angelo S, De Nooij JC, Pace-Bonello B, Shenton FC, Sanger HE, Heinz BA, Broad LM, Grosjean N, McQuillian JR, Dubini M, Pyner S, Greig I, Zanda M, Bleakman D, Banks RW, Bewick GS. Thompson KJ, et al. Among authors: bleakman d. Exp Physiol. 2024 Jan;109(1):81-99. doi: 10.1113/EP090761. Epub 2023 Sep 1. Exp Physiol. 2024. PMID: 37656490 Free PMC article. Review.
Test-retest reliability of evoked heat stimulation BOLD fMRI.
Upadhyay J, Lemme J, Anderson J, Bleakman D, Large T, Evelhoch JL, Hargreaves R, Borsook D, Becerra L. Upadhyay J, et al. Among authors: bleakman d. J Neurosci Methods. 2015 Sep 30;253:38-46. doi: 10.1016/j.jneumeth.2015.06.001. Epub 2015 Jun 10. J Neurosci Methods. 2015. PMID: 26072245
GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.
Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Clawson DK, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL. Martinez-Perez JA, et al. Among authors: bleakman d. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6463-6. doi: 10.1016/j.bmcl.2013.09.045. Epub 2013 Sep 24. Bioorg Med Chem Lett. 2013. PMID: 24140446
GluK1 antagonists from 6-(carboxy)phenyl decahydroisoquinoline derivatives. SAR and evaluation of a prodrug strategy for oral efficacy in pain models.
Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL. Martinez-Perez JA, et al. Among authors: bleakman d. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6459-62. doi: 10.1016/j.bmcl.2013.09.046. Epub 2013 Sep 25. Bioorg Med Chem Lett. 2013. PMID: 24119554
Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects.
Becerra L, Upadhyay J, Chang PC, Bishop J, Anderson J, Baumgartner R, Schwarz AJ, Coimbra A, Wallin D, Nutile L, George E, Maier G, Sunkaraneni S, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Borsook D. Becerra L, et al. Among authors: bleakman d. J Pharmacol Exp Ther. 2013 Apr;345(1):41-51. doi: 10.1124/jpet.112.201145. Epub 2013 Jan 31. J Pharmacol Exp Ther. 2013. PMID: 23370795 Clinical Trial.
Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain.
Borsook D, Upadhyay J, Klimas M, Schwarz AJ, Coimbra A, Baumgartner R, George E, Potter WZ, Large T, Bleakman D, Evelhoch J, Iyengar S, Becerra L, Hargreaves RJ. Borsook D, et al. Among authors: bleakman d. Drug Discov Today. 2012 Sep;17(17-18):964-73. doi: 10.1016/j.drudis.2012.05.004. Epub 2012 May 10. Drug Discov Today. 2012. PMID: 22579743 Review.
Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine.
Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Schwarz AJ, Pendse G, Wallin D, Nutile L, Bishop J, George E, Elman I, Sunkaraneni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Upadhyay J, et al. Among authors: bleakman d. Neuroimage. 2012 Feb 15;59(4):3762-73. doi: 10.1016/j.neuroimage.2011.11.034. Epub 2011 Nov 18. Neuroimage. 2012. PMID: 22119647
Imaging drugs with and without clinical analgesic efficacy.
Upadhyay J, Anderson J, Schwarz AJ, Coimbra A, Baumgartner R, Pendse G, George E, Nutile L, Wallin D, Bishop J, Neni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Upadhyay J, et al. Among authors: bleakman d. Neuropsychopharmacology. 2011 Dec;36(13):2659-73. doi: 10.1038/npp.2011.156. Epub 2011 Aug 17. Neuropsychopharmacology. 2011. PMID: 21849979 Free PMC article. Clinical Trial.
92 results