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SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Nat Commun. 2020 Oct 2;11(1):4938. doi: 10.1038/s41467-020-18764-3.
Nat Commun. 2020.
PMID: 33009401
Free PMC article.
Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Olagnier D, Farahani E, Thyrsted J, Blay-Cadanet J, Herengt A, Idorn M, Hait A, Hernaez B, Knudsen A, Iversen MB, Schilling M, Jørgensen SE, Thomsen M, Reinert LS, Lappe M, Hoang HD, Gilchrist VH, Hansen AL, Ottosen R, Nielsen CG, Møller C, van der Horst D, Peri S, Balachandran S, Huang J, Jakobsen M, Svenningsen EB, Poulsen TB, Bartsch L, Thielke AL, Luo Y, Alain T, Rehwinkel J, Alcamí A, Hiscott J, Mogensen TH, Paludan SR, Holm CK.
Olagnier D, et al. Among authors: blay cadanet j.
Nat Commun. 2020 Oct 21;11(1):5419. doi: 10.1038/s41467-020-19363-y.
Nat Commun. 2020.
PMID: 33087717
Free PMC article.
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Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro.
Svenningsen EB, Thyrsted J, Blay-Cadanet J, Liu H, Lin S, Moyano-Villameriel J, Olagnier D, Idorn M, Paludan SR, Holm CK, Poulsen TB.
Svenningsen EB, et al. Among authors: blay cadanet j.
Antiviral Res. 2021 Jan;185:104988. doi: 10.1016/j.antiviral.2020.104988. Epub 2020 Nov 25.
Antiviral Res. 2021.
PMID: 33248195
Free PMC article.
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SARS-CoV-2 evades immune detection in alveolar macrophages.
Dalskov L, Møhlenberg M, Thyrsted J, Blay-Cadanet J, Poulsen ET, Folkersen BH, Skaarup SH, Olagnier D, Reinert L, Enghild JJ, Hoffmann HJ, Holm CK, Hartmann R.
Dalskov L, et al. Among authors: blay cadanet j.
EMBO Rep. 2020 Dec 3;21(12):e51252. doi: 10.15252/embr.202051252. Epub 2020 Oct 28.
EMBO Rep. 2020.
PMID: 33112036
Free PMC article.
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Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium.
Thyrsted J, Storgaard J, Blay-Cadanet J, Heinz A, Thielke AL, Crotta S, de Paoli F, Olagnier D, Wack A, Hiller K, Hansen AL, Holm CK.
Thyrsted J, et al. Among authors: blay cadanet j.
iScience. 2021 Nov 19;24(11):103300. doi: 10.1016/j.isci.2021.103300. Epub 2021 Oct 15.
iScience. 2021.
PMID: 34746710
Free PMC article.
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Cellular Metabolites Regulate Central Nucleic Acid Sensing Pathways.
Blay-Cadanet J, Pedersen A, Holm CK.
Blay-Cadanet J, et al.
Front Immunol. 2021 Feb 19;12:635738. doi: 10.3389/fimmu.2021.635738. eCollection 2021.
Front Immunol. 2021.
PMID: 33679790
Free PMC article.
Review.
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Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.
He W, Henne A, Lauterbach M, Geißmar E, Nikolka F, Kho C, Heinz A, Dostert C, Grusdat M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J, Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E, Abdullah Z, Latz E, Brenner D, Hiller K.
He W, et al. Among authors: blay cadanet j.
Nat Metab. 2022 May;4(5):524-533. doi: 10.1038/s42255-022-00565-1. Epub 2022 Jun 2.
Nat Metab. 2022.
PMID: 35655024
Free PMC article.
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