Blaskovich MA - Search Results

1

Tipifarnib-mediated suppression of T-bet-dependent signaling pathways.

Bai F, Villagra AV, Zou J, Painter JS, Connolly K, Blaskovich MA, Sokol L, Sebti S, Djeu JY, Loughran TP, Wei S, Sotomayor E, Epling-Burnette P. Bai F, et al. Among authors: blaskovich ma. Cancer Immunol Immunother. 2012 Apr;61(4):523-33. doi: 10.1007/s00262-011-1109-0. Epub 2011 Oct 9. Cancer Immunol Immunother. 2012. PMID: 21983879 Free PMC article.

2

Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling.

Epling-Burnette PK, Sokol L, Chen X, Bai F, Zhou J, Blaskovich MA, Zou J, Painter JS, Edwards TD, Moscinski L, Yoder JA, Djeu JY, Sebti S, Loughran TP Jr, Wei S. Epling-Burnette PK, et al. Among authors: blaskovich ma. Blood. 2008 Dec 1;112(12):4694-8. doi: 10.1182/blood-2008-02-136382. Epub 2008 Sep 12. Blood. 2008. PMID: 18791165 Free PMC article.

3

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Blaskovich MA, et al. Cancer Res. 2003 Mar 15;63(6):1270-9. Cancer Res. 2003. PMID: 12649187

4

The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.

Ohkanda J, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. Among authors: blaskovich ma. Prog Cell Cycle Res. 2003;5:211-7. Prog Cell Cycle Res. 2003. PMID: 14593715 Review.

5

A phase I clinical-pharmacodynamic study of the farnesyltransferase inhibitor tipifarnib in combination with the proteasome inhibitor bortezomib in advanced acute leukemias.

Lancet JE, Duong VH, Winton EF, Stuart RK, Burton M, Zhang S, Cubitt C, Blaskovich MA, Wright JJ, Sebti S, Sullivan DM. Lancet JE, et al. Among authors: blaskovich ma. Clin Cancer Res. 2011 Mar 1;17(5):1140-6. doi: 10.1158/1078-0432.CCR-10-1878. Epub 2011 Jan 13. Clin Cancer Res. 2011. PMID: 21233404 Free PMC article. Clinical Trial.

6

Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours.

Zhang X, Blaskovich MA, Forinash KD, Sebti SM. Zhang X, et al. Among authors: blaskovich ma. Br J Cancer. 2014 Aug 26;111(5):894-902. doi: 10.1038/bjc.2014.349. Epub 2014 Jul 1. Br J Cancer. 2014. PMID: 24983364 Free PMC article.

7

Activation of dendritic cells via inhibition of Jak2/STAT3 signaling.

Nefedova Y, Cheng P, Gilkes D, Blaskovich M, Beg AA, Sebti SM, Gabrilovich DI. Nefedova Y, et al. J Immunol. 2005 Oct 1;175(7):4338-46. doi: 10.4049/jimmunol.175.7.4338. J Immunol. 2005. PMID: 16177074 Free PMC article.

8

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.

Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, Hamilton AD, Sebti SM. Sun J, et al. Among authors: blaskovich ma. Cancer Res. 1999 Oct 1;59(19):4919-26. Cancer Res. 1999. PMID: 10519405

9

Lysophosphatidic acid acyltransferase beta regulates mTOR signaling.

Blaskovich MA, Yendluri V, Lawrence HR, Lawrence NJ, Sebti SM, Springett GM. Blaskovich MA, et al. PLoS One. 2013 Oct 31;8(10):e78632. doi: 10.1371/journal.pone.0078632. eCollection 2013. PLoS One. 2013. PMID: 24205284 Free PMC article.

10

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.

Delarue FL, Adnane J, Joshi B, Blaskovich MA, Wang DA, Hawker J, Bizouarn F, Ohkanda J, Zhu K, Hamilton AD, Chellappan S, Sebti SM. Delarue FL, et al. Among authors: blaskovich ma. Oncogene. 2007 Feb 1;26(5):633-40. doi: 10.1038/sj.onc.1209819. Epub 2006 Aug 14. Oncogene. 2007. PMID: 16909123

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