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Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment.
Lechner L, Opitz R, Silver MJ, Krabusch PM, Prentice AM, Field MS, Stachelscheid H, Leitão E, Schröder C, Fernandez Vallone V, Horsthemke B, Jöckel KH, Schmidt B, Nöthen MM, Hoffmann P, Herms S, Kleyn PW, Megges M, Blume-Peytavi U, Weiss K, Mai K, Blankenstein O, Obermayer B, Wiegand S, Kühnen P. Lechner L, et al. Among authors: blankenstein o. Sci Transl Med. 2023 Jul 19;15(705):eadg1659. doi: 10.1126/scitranslmed.adg1659. Epub 2023 Jul 19. Sci Transl Med. 2023. PMID: 37467315
Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist.
Kühnen P, Clément K, Wiegand S, Blankenstein O, Gottesdiener K, Martini LL, Mai K, Blume-Peytavi U, Grüters A, Krude H. Kühnen P, et al. Among authors: blankenstein o. N Engl J Med. 2016 Jul 21;375(3):240-6. doi: 10.1056/NEJMoa1512693. N Engl J Med. 2016. PMID: 27468060 Free article. Clinical Trial.
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.
Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P. Clément K, et al. Among authors: blankenstein o. Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7. Nat Med. 2018. PMID: 29736023 Clinical Trial.
Sleep Timing in Patients with Precocious and Delayed Pubertal Development.
Jessen E, Vetter C, Roenneberg T, Liesenkötter KP, Werner H, Jenni OG, Lankes E, Blankenstein O, Neumann U, Köhler B, Wiegand S, Krude H, Kühnen P. Jessen E, et al. Among authors: blankenstein o. Clocks Sleep. 2019 Feb 16;1(1):140-150. doi: 10.3390/clockssleep1010013. eCollection 2019 Mar. Clocks Sleep. 2019. PMID: 33089160 Free PMC article.
92 results