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A common mechanism of Sec61 translocon inhibition by small molecules.
Itskanov S, Wang L, Junne T, Sherriff R, Xiao L, Blanchard N, Shi WQ, Forsyth C, Hoepfner D, Spiess M, Park E. Itskanov S, et al. Among authors: blanchard n. Nat Chem Biol. 2023 Sep;19(9):1063-1071. doi: 10.1038/s41589-023-01337-y. Epub 2023 May 11. Nat Chem Biol. 2023. PMID: 37169959
Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.
Zong G, Hu Z, O'Keefe S, Tranter D, Iannotti MJ, Baron L, Hall B, Corfield K, Paatero AO, Henderson MJ, Roboti P, Zhou J, Sun X, Govindarajan M, Rohde JM, Blanchard N, Simmonds R, Inglese J, Du Y, Demangel C, High S, Paavilainen VO, Shi WQ. Zong G, et al. Among authors: blanchard n. J Am Chem Soc. 2019 May 29;141(21):8450-8461. doi: 10.1021/jacs.8b13506. Epub 2019 May 15. J Am Chem Soc. 2019. PMID: 31059257 Free PMC article.
Mycolactone subverts immunity by selectively blocking the Sec61 translocon.
Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C. Baron L, et al. Among authors: blanchard n. J Exp Med. 2016 Dec 12;213(13):2885-2896. doi: 10.1084/jem.20160662. Epub 2016 Nov 7. J Exp Med. 2016. PMID: 27821549 Free PMC article.
Formation of N-heterocyclic carbene-boryl radicals through electrochemical and photochemical cleavage of the B-S bond in N-heterocyclic carbene-boryl sulfides.
Telitel S, Vallet AL, Schweizer S, Delpech B, Blanchard N, Morlet-Savary F, Graff B, Curran DP, Robert M, Lacôte E, Lalevée J. Telitel S, et al. Among authors: blanchard n. J Am Chem Soc. 2013 Nov 13;135(45):16938-47. doi: 10.1021/ja4066267. Epub 2013 Oct 29. J Am Chem Soc. 2013. PMID: 24111491
Expanding Radical Chloropentafluorosulfanylation of Alkynes.
Nguyen TM, Popek L, Matchavariani D, Blanchard N, Bizet V, Cahard D. Nguyen TM, et al. Among authors: blanchard n. Org Lett. 2024 Jan 12;26(1):365-369. doi: 10.1021/acs.orglett.3c04043. Epub 2024 Jan 2. Org Lett. 2024. PMID: 38166239
199 results