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Page 1
The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain.
Brown AD, Bagal SK, Blackwell P, Blakemore DC, Brown B, Bungay PJ, Corless M, Crawforth J, Fengas D, Fenwick DR, Gray V, Kemp M, Klute W, Malet Sanz L, Miller D, Murata Y, Payne CE, Skerratt S, Stevens EB, Warmus JS. Brown AD, et al. Among authors: blakemore dc. Bioorg Med Chem. 2019 Jan 1;27(1):230-239. doi: 10.1016/j.bmc.2018.12.002. Epub 2018 Dec 4. Bioorg Med Chem. 2019. PMID: 30538065
The design and discovery of novel amide CCR5 antagonists.
Pryde DC, Corless M, Fenwick DR, Mason HJ, Stammen BC, Stephenson PT, Ellis D, Bachelor D, Gordon D, Barber CG, Wood A, Middleton DS, Blakemore DC, Parsons GC, Eastwood R, Platts MY, Statham K, Paradowski KA, Burt C, Klute W. Pryde DC, et al. Among authors: blakemore dc. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1084-8. doi: 10.1016/j.bmcl.2009.01.012. Epub 2009 Jan 10. Bioorg Med Chem Lett. 2009. PMID: 19167884
Synthesis and in vivo evaluation of 3-substituted gababutins.
Blakemore DC, Bryans JS, Carnell P, Chessum NE, Field MJ, Kinsella N, Kinsora JK, Osborne SA, Williams SC. Blakemore DC, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):362-5. doi: 10.1016/j.bmcl.2009.10.089. Epub 2009 Oct 25. Bioorg Med Chem Lett. 2010. PMID: 19897364
Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.
Blakemore DC, Bryans JS, Carnell P, Field MJ, Kinsella N, Kinsora JK, Meltzer LT, Osborne SA, Thompson LR, Williams SC. Blakemore DC, et al. Bioorg Med Chem Lett. 2010 Jan 1;20(1):248-51. doi: 10.1016/j.bmcl.2009.10.121. Epub 2009 Oct 30. Bioorg Med Chem Lett. 2010. PMID: 19910190
Synthesis and in vivo evaluation of bicyclic gababutins.
Blakemore DC, Bryans JS, Carnell P, Carr CL, Chessum NE, Field MJ, Kinsella N, Osborne SA, Warren AN, Williams SC. Blakemore DC, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):461-4. doi: 10.1016/j.bmcl.2009.11.118. Epub 2009 Nov 27. Bioorg Med Chem Lett. 2010. PMID: 20005103
Part 1: N-alkylated glycines as potent α2δ ligands.
Thompson LR, Blakemore DC, Brugier D, Bryans JS, Chu WL, Maw GN, Poinsard C, Rawson DJ, Warren AN. Thompson LR, et al. Among authors: blakemore dc. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3764-6. doi: 10.1016/j.bmcl.2011.04.045. Epub 2011 Apr 30. Bioorg Med Chem Lett. 2011. PMID: 21601457
65 results