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Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.
Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M. Oroz J, et al. Among authors: blair lj. Nat Commun. 2018 Oct 31;9(1):4532. doi: 10.1038/s41467-018-06880-0. Nat Commun. 2018. PMID: 30382094 Free PMC article.
Facilitating Akt clearance via manipulation of Hsp70 activity and levels.
Koren J 3rd, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Koren J 3rd, et al. Among authors: blair lj. J Biol Chem. 2010 Jan 22;285(4):2498-505. doi: 10.1074/jbc.M109.057208. Epub 2009 Nov 4. J Biol Chem. 2010. PMID: 19889640 Free PMC article.
The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.
Jinwal UK, Koren J 3rd, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC 3rd, Jin Y, Buchner J, Cox MB, Dickey CA. Jinwal UK, et al. Among authors: blair lj. J Neurosci. 2010 Jan 13;30(2):591-9. doi: 10.1523/JNEUROSCI.4815-09.2010. J Neurosci. 2010. PMID: 20071522 Free PMC article.
Hsc70 rapidly engages tau after microtubule destabilization.
Jinwal UK, O'Leary JC 3rd, Borysov SI, Jones JR, Li Q, Koren J 3rd, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA. Jinwal UK, et al. Among authors: blair lj. J Biol Chem. 2010 May 28;285(22):16798-805. doi: 10.1074/jbc.M110.113753. Epub 2010 Mar 22. J Biol Chem. 2010. PMID: 20308058 Free PMC article.
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.
O'Leary JC 3rd, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J 3rd, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA. O'Leary JC 3rd, et al. Among authors: blair lj. Mol Neurodegener. 2010 Nov 1;5:45. doi: 10.1186/1750-1326-5-45. Mol Neurodegener. 2010. PMID: 21040568 Free PMC article.
Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.
Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J 3rd, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, Weeber EJ, Banko J, Dickey CA. Abisambra JF, et al. Among authors: blair lj. J Neurosci. 2010 Nov 17;30(46):15374-82. doi: 10.1523/JNEUROSCI.3155-10.2010. J Neurosci. 2010. PMID: 21084594 Free PMC article.
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
O'Leary JC 3rd, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA. O'Leary JC 3rd, et al. Among authors: blair lj. PLoS One. 2011;6(9):e24840. doi: 10.1371/journal.pone.0024840. Epub 2011 Sep 15. PLoS One. 2011. PMID: 21935478 Free PMC article.
86 results