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Optimized chemical probes for REV-ERBα.
Trump RP, Bresciani S, Cooper AW, Tellam JP, Wojno J, Blaikley J, Orband-Miller LA, Kashatus JA, Boudjelal M, Dawson HC, Loudon A, Ray D, Grant D, Farrow SN, Willson TM, Tomkinson NC. Trump RP, et al. Among authors: blaikley j. J Med Chem. 2013 Jun 13;56(11):4729-37. doi: 10.1021/jm400458q. Epub 2013 May 23. J Med Chem. 2013. PMID: 23656296 Free PMC article.
The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.
Gibbs JE, Blaikley J, Beesley S, Matthews L, Simpson KD, Boyce SH, Farrow SN, Else KJ, Singh D, Ray DW, Loudon AS. Gibbs JE, et al. Among authors: blaikley j. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):582-7. doi: 10.1073/pnas.1106750109. Epub 2011 Dec 19. Proc Natl Acad Sci U S A. 2012. PMID: 22184247 Free PMC article.
Circadian asthma airway responses are gated by REV-ERBα.
Durrington HJ, Krakowiak K, Meijer P, Begley N, Maidstone R, Goosey L, Gibbs JE, Blaikley JF, Gregory LG, Lloyd CM, Loudon ASI, Ray DW. Durrington HJ, et al. Among authors: blaikley jf. Eur Respir J. 2020 Dec 17;56(6):1902407. doi: 10.1183/13993003.02407-2019. Print 2020 Dec. Eur Respir J. 2020. PMID: 32586876 Free PMC article.
Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and Treatment.
Durrington HJ, Gioan-Tavernier GO, Maidstone RJ, Krakowiak K, Loudon ASI, Blaikley JF, Fowler SJ, Singh D, Simpson A, Ray DW. Durrington HJ, et al. Among authors: blaikley jf. Am J Respir Crit Care Med. 2018 Dec 15;198(12):1578-1581. doi: 10.1164/rccm.201807-1289LE. Am J Respir Crit Care Med. 2018. PMID: 30156881 Free PMC article. No abstract available.
Circadian rhythm of exhaled biomarkers in health and asthma.
Wilkinson M, Maidstone R, Loudon A, Blaikley J, White IR, Singh D, Ray DW, Goodacre R, Fowler SJ, Durrington HJ. Wilkinson M, et al. Among authors: blaikley j. Eur Respir J. 2019 Oct 17;54(4):1901068. doi: 10.1183/13993003.01068-2019. Print 2019 Oct. Eur Respir J. 2019. PMID: 31221808 Free PMC article.
Night shift work is associated with an increased risk of asthma.
Maidstone RJ, Turner J, Vetter C, Dashti HS, Saxena R, Scheer FAJL, Shea SA, Kyle SD, Lawlor DA, Loudon ASI, Blaikley JF, Rutter MK, Ray DW, Durrington HJ. Maidstone RJ, et al. Among authors: blaikley jf. Thorax. 2021 Jan;76(1):53-60. doi: 10.1136/thoraxjnl-2020-215218. Epub 2020 Nov 16. Thorax. 2021. PMID: 33199525 Free PMC article.
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Kitchen GB, Cunningham PS, Poolman TM, Iqbal M, Maidstone R, Baxter M, Bagnall J, Begley N, Saer B, Hussell T, Matthews LC, Dockrell DH, Durrington HJ, Gibbs JE, Blaikley JF, Loudon AS, Ray DW. Kitchen GB, et al. Among authors: blaikley jf. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1543-1551. doi: 10.1073/pnas.1915932117. Epub 2020 Jan 3. Proc Natl Acad Sci U S A. 2020. PMID: 31900362 Free PMC article.
Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion.
Zhang Z, Hunter L, Wu G, Maidstone R, Mizoro Y, Vonslow R, Fife M, Hopwood T, Begley N, Saer B, Wang P, Cunningham P, Baxter M, Durrington H, Blaikley JF, Hussell T, Rattray M, Hogenesch JB, Gibbs J, Ray DW, Loudon ASI. Zhang Z, et al. Among authors: blaikley jf. FASEB J. 2019 May;33(5):6226-6238. doi: 10.1096/fj.201801682R. Epub 2019 Feb 22. FASEB J. 2019. PMID: 30794439 Free PMC article.
., Saer, B., Wang, P., Cunningham, P., Baxter, M., Durrington, H., Blaikley, J. F., Hussell, T., Rattray, M., Hogenesch, J. B., Gibbs, J., Ray, D. ...
., Saer, B., Wang, P., Cunningham, P., Baxter, M., Durrington, H., Blaikley, J. F., Hussell, T., Rattray, M., Hogenesch, J …
73 results