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MEPIRAPIM-derived synthetic cannabinoids inhibit T-type calcium channels with divergent effects on seizures in rodent models of epilepsy.
Harman T, Udoh M, McElroy DL, Anderson LL, Kevin RC, Banister SD, Ametovski A, Markham J, Bladen C, Doohan PT, Greba Q, Laprairie RB, Snutch TP, McGregor IS, Howland JG, Arnold JC. Harman T, et al. Among authors: bladen c. Front Physiol. 2023 Apr 4;14:1086243. doi: 10.3389/fphys.2023.1086243. eCollection 2023. Front Physiol. 2023. PMID: 37082241 Free PMC article.
Putative Synthetic Cannabinoids MEPIRAPIM, 5F-BEPIRAPIM (NNL-2), and Their Analogues Are T-Type Calcium Channel (CaV3) Inhibitors.
Kevin RC, Mirlohi S, Manning JJ, Boyd R, Cairns EA, Ametovski A, Lai F, Luo JL, Jorgensen W, Ellison R, Gerona RR, Hibbs DE, McGregor IS, Glass M, Connor M, Bladen C, Zamponi GW, Banister SD. Kevin RC, et al. Among authors: bladen c. ACS Chem Neurosci. 2022 May 4;13(9):1395-1409. doi: 10.1021/acschemneuro.1c00822. Epub 2022 Apr 20. ACS Chem Neurosci. 2022. PMID: 35442021
A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain.
Hildebrand ME, Smith PL, Bladen C, Eduljee C, Xie JY, Chen L, Fee-Maki M, Doering CJ, Mezeyova J, Zhu Y, Belardetti F, Pajouhesh H, Parker D, Arneric SP, Parmar M, Porreca F, Tringham E, Zamponi GW, Snutch TP. Hildebrand ME, et al. Among authors: bladen c. Pain. 2011 Apr;152(4):833-843. doi: 10.1016/j.pain.2010.12.035. Epub 2011 Feb 23. Pain. 2011. PMID: 21349638
59 results