Blacklow SC - Search Results

1

Targeted Degradation of the Oncogenic Phosphatase SHP2.

Vemulapalli V, Donovan KA, Seegar TCM, Rogers JM, Bae M, Lumpkin RJ, Cao R, Henke MT, Ray SS, Fischer ES, Cuny GD, Blacklow SC. Vemulapalli V, et al. Among authors: blacklow sc. Biochemistry. 2021 Aug 31;60(34):2593-2609. doi: 10.1021/acs.biochem.1c00377. Epub 2021 Aug 19. Biochemistry. 2021. PMID: 34411482 Free PMC article.

2

Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1.

Vardar D, North CL, Sanchez-Irizarry C, Aster JC, Blacklow SC. Vardar D, et al. Among authors: blacklow sc. Biochemistry. 2003 Jun 17;42(23):7061-7. doi: 10.1021/bi034156y. Biochemistry. 2003. PMID: 12795601

3

Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.

LaRochelle JR, Fodor M, Xu X, Durzynska I, Fan L, Stams T, Chan HM, LaMarche MJ, Chopra R, Wang P, Fortin PD, Acker MG, Blacklow SC. LaRochelle JR, et al. Among authors: blacklow sc. Biochemistry. 2016 Apr 19;55(15):2269-77. doi: 10.1021/acs.biochem.5b01287. Epub 2016 Apr 11. Biochemistry. 2016. PMID: 27030275 Free PMC article.

4

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.

Zimmerman B, Kelly B, McMillan BJ, Seegar TCM, Dror RO, Kruse AC, Blacklow SC. Zimmerman B, et al. Among authors: blacklow sc. Cell. 2016 Nov 3;167(4):1041-1051.e11. doi: 10.1016/j.cell.2016.09.056. Epub 2016 Oct 27. Cell. 2016. PMID: 27881302 Free PMC article.

5

Structural Basis for Regulation of ESCRT-III Complexes by Lgd.

McMillan BJ, Tibbe C, Drabek AA, Seegar TCM, Blacklow SC, Klein T. McMillan BJ, et al. Among authors: blacklow sc. Cell Rep. 2017 May 30;19(9):1750-1757. doi: 10.1016/j.celrep.2017.05.026. Cell Rep. 2017. PMID: 28564595 Free PMC article.

6

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.

LaRochelle JR, Fodor M, Ellegast JM, Liu X, Vemulapalli V, Mohseni M, Stams T, Buhrlage SJ, Stegmaier K, LaMarche MJ, Acker MG, Blacklow SC. LaRochelle JR, et al. Among authors: blacklow sc. Bioorg Med Chem. 2017 Dec 15;25(24):6479-6485. doi: 10.1016/j.bmc.2017.10.025. Epub 2017 Oct 20. Bioorg Med Chem. 2017. PMID: 29089257

7

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.

Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Seegar TCM, et al. Among authors: blacklow sc. Cell. 2017 Dec 14;171(7):1638-1648.e7. doi: 10.1016/j.cell.2017.11.014. Epub 2017 Dec 7. Cell. 2017. PMID: 29224781 Free PMC article.

8

Dual Allosteric Inhibition of SHP2 Phosphatase.

Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, Glick M, Hao HX, Kato M, Koenig R, LaRochelle JR, Liu G, McNeill E, Majumdar D, Nishiguchi GA, Perez LB, Paris G, Quinn CM, Ramsey T, Sendzik M, Shultz MD, Williams SL, Stams T, Blacklow SC, Acker MG, LaMarche MJ. Fodor M, et al. Among authors: blacklow sc. ACS Chem Biol. 2018 Mar 16;13(3):647-656. doi: 10.1021/acschembio.7b00980. Epub 2018 Jan 18. ACS Chem Biol. 2018. PMID: 29304282

9

Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.

LaRochelle JR, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, LaMarche MJ, Chopra R, Acker MG, Blacklow SC. LaRochelle JR, et al. Among authors: blacklow sc. Nat Commun. 2018 Oct 30;9(1):4508. doi: 10.1038/s41467-018-06823-9. Nat Commun. 2018. PMID: 30375388 Free PMC article.

10

Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.

Rogers JM, Waters CT, Seegar TCM, Jarrett SM, Hallworth AN, Blacklow SC, Bulyk ML. Rogers JM, et al. Among authors: blacklow sc. Mol Cell. 2019 Apr 18;74(2):245-253.e6. doi: 10.1016/j.molcel.2019.01.019. Epub 2019 Feb 27. Mol Cell. 2019. PMID: 30826165 Free PMC article.

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