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Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.
Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS. Wang J, et al. Among authors: blacklow sc. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31. ACS Chem Biol. 2018. PMID: 30102854 Free PMC article.
Direct inhibition of the NOTCH transcription factor complex.
Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE. Moellering RE, et al. Among authors: blacklow sc. Nature. 2009 Nov 12;462(7270):182-8. doi: 10.1038/nature08543. Nature. 2009. PMID: 19907488 Free PMC article.
Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.
Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC. Andrawes MB, et al. Among authors: blacklow sc. J Biol Chem. 2013 Aug 30;288(35):25477-25489. doi: 10.1074/jbc.M113.454850. Epub 2013 Jul 9. J Biol Chem. 2013. PMID: 23839946 Free PMC article.
Biased multicomponent reactions to develop novel bromodomain inhibitors.
McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE. McKeown MR, et al. Among authors: blacklow sc. J Med Chem. 2014 Nov 13;57(21):9019-27. doi: 10.1021/jm501120z. Epub 2014 Oct 31. J Med Chem. 2014. PMID: 25314271 Free PMC article.
Structural Basis for Substrate Selectivity of the E3 Ligase COP1.
Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC. Uljon S, et al. Among authors: blacklow sc. Structure. 2016 May 3;24(5):687-696. doi: 10.1016/j.str.2016.03.002. Epub 2016 Mar 31. Structure. 2016. PMID: 27041596 Free PMC article.
STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.
Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC. Durzynska I, et al. Among authors: blacklow sc. Structure. 2017 Feb 7;25(2):287-294. doi: 10.1016/j.str.2016.12.008. Epub 2017 Jan 12. Structure. 2017. PMID: 28089446 Free PMC article.
Dual Allosteric Inhibition of SHP2 Phosphatase.
Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, Glick M, Hao HX, Kato M, Koenig R, LaRochelle JR, Liu G, McNeill E, Majumdar D, Nishiguchi GA, Perez LB, Paris G, Quinn CM, Ramsey T, Sendzik M, Shultz MD, Williams SL, Stams T, Blacklow SC, Acker MG, LaMarche MJ. Fodor M, et al. Among authors: blacklow sc. ACS Chem Biol. 2018 Mar 16;13(3):647-656. doi: 10.1021/acschembio.7b00980. Epub 2018 Jan 18. ACS Chem Biol. 2018. PMID: 29304282
Structural basis for autoinhibition of Notch.
Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC. Gordon WR, et al. Among authors: blacklow sc. Nat Struct Mol Biol. 2007 Apr;14(4):295-300. doi: 10.1038/nsmb1227. Epub 2007 Apr 1. Nat Struct Mol Biol. 2007. PMID: 17401372
165 results