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Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.
Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M. Ito TK, et al. Among authors: bitto a. Front Genet. 2017 Sep 1;8:113. doi: 10.3389/fgene.2017.00113. eCollection 2017. Front Genet. 2017. PMID: 28919908 Free PMC article.
Rejuvenation: it's in our blood.
Bitto A, Kaeberlein M. Bitto A, et al. Cell Metab. 2014 Jul 1;20(1):2-4. doi: 10.1016/j.cmet.2014.06.007. Cell Metab. 2014. PMID: 24988454 Free PMC article.
Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice.
Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, Van Den Ende A, Rabinovitch PS, Suh Y, Kaeberlein M. Johnson SC, et al. Among authors: bitto a. Front Genet. 2015 Jul 22;6:247. doi: 10.3389/fgene.2015.00247. eCollection 2015. Front Genet. 2015. PMID: 26257774 Free PMC article.
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.
Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, Gillespie CH, Snyder JM, Treuting PM, Kaeberlein M. Bitto A, et al. Elife. 2016 Aug 23;5:e16351. doi: 10.7554/eLife.16351. Elife. 2016. PMID: 27549339 Free PMC article.
Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.
Bennett CF, Kwon JJ, Chen C, Russell J, Acosta K, Burnaevskiy N, Crane MM, Bitto A, Vander Wende H, Simko M, Pineda V, Rossner R, Wasko BM, Choi H, Chen S, Park S, Jafari G, Sands B, Perez Olsen C, Mendenhall AR, Morgan PG, Kaeberlein M. Bennett CF, et al. Among authors: bitto a. PLoS Genet. 2017 Mar 29;13(3):e1006695. doi: 10.1371/journal.pgen.1006695. eCollection 2017 Mar. PLoS Genet. 2017. PMID: 28355222 Free PMC article.
Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.
Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips JJ, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, Wang W, Bitto A, An JY, Morton JF, Setou M, Ladiges WC, Kaeberlein M. Ito TK, et al. Among authors: bitto a. Front Genet. 2017 Dec 22;8:221. doi: 10.3389/fgene.2017.00221. eCollection 2017. Front Genet. 2017. PMID: 29285026 Free PMC article.
Regional metabolic signatures in the Ndufs4(KO) mouse brain implicate defective glutamate/α-ketoglutarate metabolism in mitochondrial disease.
Johnson SC, Kayser EB, Bornstein R, Stokes J, Bitto A, Park KY, Pan A, Sun G, Raftery D, Kaeberlein M, Sedensky MM, Morgan PG. Johnson SC, et al. Among authors: bitto a. Mol Genet Metab. 2020 Jun;130(2):118-132. doi: 10.1016/j.ymgme.2020.03.007. Epub 2020 Apr 3. Mol Genet Metab. 2020. PMID: 32331968 Free PMC article.
288 results