Bitsi S - Search Results

1

Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells.

Fang Z, Chen S, Manchanda Y, Bitsi S, Pickford P, David A, Shchepinova MM, Corrêa IR Jr, Hodson DJ, Broichhagen J, Tate EW, Reimann F, Salem V, Rutter GA, Tan T, Bloom SR, Tomas A, Jones B. Fang Z, et al. Among authors: bitsi s. Int J Mol Sci. 2020 Nov 9;21(21):8404. doi: 10.3390/ijms21218404. Int J Mol Sci. 2020. PMID: 33182425 Free PMC article.

2

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

Buenaventura T, Bitsi S, Laughlin WE, Burgoyne T, Lyu Z, Oqua AI, Norman H, McGlone ER, Klymchenko AS, Corrêa IR Jr, Walker A, Inoue A, Hanyaloglu A, Grimes J, Koszegi Z, Calebiro D, Rutter GA, Bloom SR, Jones B, Tomas A. Buenaventura T, et al. Among authors: bitsi s. PLoS Biol. 2019 Aug 20;17(8):e3000097. doi: 10.1371/journal.pbio.3000097. eCollection 2019 Aug. PLoS Biol. 2019. PMID: 31430273 Free PMC article.

3

Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking.

Fremaux J, Venin C, Mauran L, Zimmer R, Koensgen F, Rognan D, Bitsi S, Lucey MA, Jones B, Tomas A, Guichard G, Goudreau SR. Fremaux J, et al. Among authors: bitsi s. Chem Sci. 2019 Sep 11;10(42):9872-9879. doi: 10.1039/c9sc02079a. eCollection 2019 Nov 14. Chem Sci. 2019. PMID: 32015811 Free PMC article.

4

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists.

Lucey M, Pickford P, Bitsi S, Minnion J, Ungewiss J, Schoeneberg K, Rutter GA, Bloom SR, Tomas A, Jones B. Lucey M, et al. Among authors: bitsi s. Mol Metab. 2020 Jul;37:100991. doi: 10.1016/j.molmet.2020.100991. Epub 2020 Apr 8. Mol Metab. 2020. PMID: 32278079 Free PMC article.

5

Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide.

Pickford P, Lucey M, Fang Z, Bitsi S, de la Serna JB, Broichhagen J, Hodson DJ, Minnion J, Rutter GA, Bloom SR, Tomas A, Jones B. Pickford P, et al. Among authors: bitsi s. Br J Pharmacol. 2020 Sep;177(17):3905-3923. doi: 10.1111/bph.15134. Epub 2020 Jun 19. Br J Pharmacol. 2020. PMID: 32436216 Free PMC article.

6

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist.

Pickford P, Lucey M, Rujan RM, McGlone ER, Bitsi S, Ashford FB, Corrêa IR, Hodson DJ, Tomas A, Deganutti G, Reynolds CA, Owen BM, Tan TM, Minnion J, Jones B, Bloom SR. Pickford P, et al. Among authors: bitsi s. Mol Metab. 2021 Sep;51:101242. doi: 10.1016/j.molmet.2021.101242. Epub 2021 Apr 30. Mol Metab. 2021. PMID: 33933675 Free PMC article.

7

Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells.

Manchanda Y, Bitsi S, Chen S, Broichhagen J, Bernardino de la Serna J, Jones B, Tomas A. Manchanda Y, et al. Among authors: bitsi s. Endocrinology. 2023 Mar 13;164(5):bqad028. doi: 10.1210/endocr/bqad028. Endocrinology. 2023. PMID: 36774542 Free PMC article.

8

Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice.

Bitsi S, El Eid L, Manchanda Y, Oqua AI, Mohamed N, Hansen B, Suba K, Rutter GA, Salem V, Jones B, Tomas A. Bitsi S, et al. Sci Adv. 2023 May 3;9(18):eadf7737. doi: 10.1126/sciadv.adf7737. Epub 2023 May 3. Sci Adv. 2023. PMID: 37134170 Free PMC article.

9

Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes.

Bitsi S, Ali H, Maskell L, Ounzain S, Mohamed-Ali V, Budhram-Mahadeo VS. Bitsi S, et al. Am J Physiol Endocrinol Metab. 2016 Mar 1;310(5):E303-12. doi: 10.1152/ajpendo.00211.2015. Epub 2015 Dec 15. Am J Physiol Endocrinol Metab. 2016. PMID: 26670484 Free PMC article.

10

Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults.

Budhram-Mahadeo V, Fujita R, Bitsi S, Sicard P, Heads R. Budhram-Mahadeo V, et al. Among authors: bitsi s. Cell Death Dis. 2014 Oct 30;5(10):e1503. doi: 10.1038/cddis.2014.452. Cell Death Dis. 2014. PMID: 25356872 Free PMC article.

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