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Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.
Eckardt L, Prange-Barczynska M, Hodson EJ, Fielding JW, Cheng X, Lima JDCC, Kurlekar S, Douglas G, Ratcliffe PJ, Bishop T. Eckardt L, et al. Among authors: bishop t. Endocr Relat Cancer. 2021 Oct 18;28(12):757-772. doi: 10.1530/ERC-21-0211. Endocr Relat Cancer. 2021. PMID: 34658364 Free PMC article.
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura A, Pugh CW, Ratcliffe PJ, Schofield CJ. Chan MC, et al. Among authors: bishop t. PLoS One. 2015 Jul 6;10(7):e0132004. doi: 10.1371/journal.pone.0132004. eCollection 2015. PLoS One. 2015. PMID: 26147748 Free PMC article.
PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies.
Fielding JW, Hodson EJ, Cheng X, Ferguson DJP, Eckardt L, Adam J, Lip P, Maton-Howarth M, Ratnayaka I, Pugh CW, Buckler KJ, Ratcliffe PJ, Bishop T. Fielding JW, et al. Among authors: bishop t. J Physiol. 2018 Jun 19;596(18):4393-412. doi: 10.1113/JP275996. Online ahead of print. J Physiol. 2018. PMID: 29917232 Free PMC article.
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW. Yamamoto A, et al. Among authors: bishop t. J Clin Invest. 2019 Jun 4;129(9):3640-3656. doi: 10.1172/JCI124099. J Clin Invest. 2019. PMID: 31162141 Free PMC article.
Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control.
Cheng X, Prange-Barczynska M, Fielding JW, Zhang M, Burrell AL, Lima JD, Eckardt L, Argles I, Pugh CW, Buckler KJ, Robbins PA, Hodson EJ, Bruick RK, Collinson LM, Rastinejad F, Bishop T, Ratcliffe PJ. Cheng X, et al. Among authors: bishop t. J Clin Invest. 2020 May 1;130(5):2237-2251. doi: 10.1172/JCI133194. J Clin Invest. 2020. PMID: 31999648 Free PMC article.
Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.
Wing PAC, Keeley TP, Zhuang X, Lee JY, Prange-Barczynska M, Tsukuda S, Morgan SB, Harding AC, Argles ILA, Kurlekar S, Noerenberg M, Thompson CP, Huang KA, Balfe P, Watashi K, Castello A, Hinks TSC, James W, Ratcliffe PJ, Davis I, Hodson EJ, Bishop T, McKeating JA. Wing PAC, et al. Among authors: bishop t. Cell Rep. 2021 Apr 20;35(3):109020. doi: 10.1016/j.celrep.2021.109020. Epub 2021 Apr 5. Cell Rep. 2021. PMID: 33852916 Free PMC article.
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