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4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects.
FEBS Open Bio. 2022 Feb;12(2):394-411. doi: 10.1002/2211-5463.13346. Epub 2021 Dec 18.
FEBS Open Bio. 2022.
PMID: 34873879
Free PMC article.
Broad-Spectrum Anticancer Activity and Pharmacokinetic Properties of a Prenyloxy-Substituted Indeno[1,2-b]indole Derivative, Discovered as CK2 Inhibitor.
El-Awaad E, Birus R, Marminon C, Bouaziz Z, Ballentin L, Aichele D, Le Borgne M, Jose J.
El-Awaad E, et al. Among authors: birus r.
Pharmaceuticals (Basel). 2021 Jun 5;14(6):542. doi: 10.3390/ph14060542.
Pharmaceuticals (Basel). 2021.
PMID: 34198928
Free PMC article.
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Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'.
Hochscherf J, Lindenblatt D, Witulski B, Birus R, Aichele D, Marminon C, Bouaziz Z, Le Borgne M, Jose J, Niefind K.
Hochscherf J, et al. Among authors: birus r.
Pharmaceuticals (Basel). 2017 Dec 13;10(4):98. doi: 10.3390/ph10040098.
Pharmaceuticals (Basel). 2017.
PMID: 29236079
Free PMC article.
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In Vitro and in Silico Evaluation of Bikaverin as a Potent Inhibitor of Human Protein Kinase CK2.
Haidar S, Aichele D, Birus R, Hielscher J, Laitinen T, Poso A, Jose J.
Haidar S, et al. Among authors: birus r.
Molecules. 2019 Apr 8;24(7):1380. doi: 10.3390/molecules24071380.
Molecules. 2019.
PMID: 30965682
Free PMC article.
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Covalent coupling of functionalized outer membrane vesicles (OMVs) to gold nanoparticles.
Bong JH, Dombovski A, Birus R, Cho S, Lee M, Pyun JC, Jose J.
Bong JH, et al. Among authors: birus r.
J Colloid Interface Sci. 2024 Jun;663:227-237. doi: 10.1016/j.jcis.2024.02.137. Epub 2024 Feb 18.
J Colloid Interface Sci. 2024.
PMID: 38401443
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