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The MACPF/CDC family of pore-forming toxins.
Rosado CJ, Kondos S, Bull TE, Kuiper MJ, Law RH, Buckle AM, Voskoboinik I, Bird PI, Trapani JA, Whisstock JC, Dunstone MA. Rosado CJ, et al. Among authors: bird pi. Cell Microbiol. 2008 Sep;10(9):1765-74. doi: 10.1111/j.1462-5822.2008.01191.x. Epub 2008 Jun 28. Cell Microbiol. 2008. PMID: 18564372 Free PMC article. Review.
A common fold mediates vertebrate defense and bacterial attack.
Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC. Rosado CJ, et al. Among authors: bird pi, bird ch. Science. 2007 Sep 14;317(5844):1548-51. doi: 10.1126/science.1144706. Epub 2007 Aug 23. Science. 2007. PMID: 17717151
The structural basis for membrane binding and pore formation by lymphocyte perforin.
Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC. Law RH, et al. Among authors: bird pi. Nature. 2010 Nov 18;468(7322):447-51. doi: 10.1038/nature09518. Epub 2010 Oct 31. Nature. 2010. PMID: 21037563
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Pang SS, Bayly-Jones C, Radjainia M, Spicer BA, Law RHP, Hodel AW, Parsons ES, Ekkel SM, Conroy PJ, Ramm G, Venugopal H, Bird PI, Hoogenboom BW, Voskoboinik I, Gambin Y, Sierecki E, Dunstone MA, Whisstock JC. Pang SS, et al. Among authors: bird pi. Nat Commun. 2019 Sep 19;10(1):4288. doi: 10.1038/s41467-019-12279-2. Nat Commun. 2019. PMID: 31537793 Free PMC article.
The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.
Law RH, Irving JA, Buckle AM, Ruzyla K, Buzza M, Bashtannyk-Puhalovich TA, Beddoe TC, Nguyen K, Worrall DM, Bottomley SP, Bird PI, Rossjohn J, Whisstock JC. Law RH, et al. Among authors: bird pi. J Biol Chem. 2005 Jun 10;280(23):22356-64. doi: 10.1074/jbc.M412043200. Epub 2005 Mar 10. J Biol Chem. 2005. PMID: 15760906 Free article.
Mechanisms of serpin dysfunction in disease.
Kaiserman D, Whisstock JC, Bird PI. Kaiserman D, et al. Among authors: bird pi. Expert Rev Mol Med. 2006 Dec 11;8(31):1-19. doi: 10.1017/S1462399406000184. Expert Rev Mol Med. 2006. PMID: 17156576 Review.
Structure of granzyme C reveals an unusual mechanism of protease autoinhibition.
Kaiserman D, Buckle AM, Van Damme P, Irving JA, Law RH, Matthews AY, Bashtannyk-Puhalovich T, Langendorf C, Thompson P, Vandekerckhove J, Gevaert K, Whisstock JC, Bird PI. Kaiserman D, et al. Among authors: bird pi. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5587-92. doi: 10.1073/pnas.0811968106. Epub 2009 Mar 19. Proc Natl Acad Sci U S A. 2009. PMID: 19299505 Free PMC article.
202 results