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Chronic treatment with the AMP-kinase activator AICAR increases glycogen storage and fatty acid oxidation in skeletal muscles but does not reduce hyperglucagonemia and hyperglycemia in insulin deficient rats.
Vitzel KF, Bikopoulos G, Hung S, Pistor KE, Patterson JD, Curi R, Ceddia RB. Vitzel KF, et al. Among authors: bikopoulos g. PLoS One. 2013 Apr 19;8(4):e62190. doi: 10.1371/journal.pone.0062190. Print 2013. PLoS One. 2013. PMID: 23620811 Free PMC article.
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