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Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models.
Parker S, McDowall C, Sanchez-Perez L, Osorio C, Duncker PC, Briley A, Swartz AM, Herndon JE 2nd, Yu YA, McLendon RE, Tedder TF, Desjardins A, Ashley DM, Gunn MD, Enterline DS, Knorr DA, Pastan IH, Nair SK, Bigner DD, Chandramohan V. Parker S, et al. Among authors: bigner dd. Sci Transl Med. 2023 Feb 8;15(682):eabn5649. doi: 10.1126/scitranslmed.abn5649. Epub 2023 Feb 8. Sci Transl Med. 2023. PMID: 36753564 Free PMC article.
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
Sampson JH, Schmittling RJ, Archer GE, Congdon KL, Nair SK, Reap EA, Desjardins A, Friedman AH, Friedman HS, Herndon JE 2nd, Coan A, McLendon RE, Reardon DA, Vredenburgh JJ, Bigner DD, Mitchell DA. Sampson JH, et al. Among authors: bigner dd. PLoS One. 2012;7(2):e31046. doi: 10.1371/journal.pone.0031046. Epub 2012 Feb 27. PLoS One. 2012. PMID: 22383993 Free PMC article. Clinical Trial.
Toxin-based targeted therapy for malignant brain tumors.
Chandramohan V, Sampson JH, Pastan I, Bigner DD. Chandramohan V, et al. Among authors: bigner dd. Clin Dev Immunol. 2012;2012:480429. doi: 10.1155/2012/480429. Epub 2012 Feb 9. Clin Dev Immunol. 2012. PMID: 22400035 Free PMC article. Review.
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