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A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity.
Johns A, Scharf DH, Gsaller F, Schmidt H, Heinekamp T, Straßburger M, Oliver JD, Birch M, Beckmann N, Dobb KS, Gilsenan J, Rash B, Bignell E, Brakhage AA, Bromley MJ. Johns A, et al. Among authors: bignell e. mBio. 2017 Jul 18;8(4):e01504-16. doi: 10.1128/mBio.01504-16. mBio. 2017. PMID: 28720735 Free PMC article.
Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection.
Scott J, Sueiro-Olivares M, Ahmed W, Heddergott C, Zhao C, Thomas R, Bromley M, Latgé JP, Krappmann S, Fowler S, Bignell E, Amich J. Scott J, et al. Among authors: bignell e. Front Microbiol. 2019 Oct 9;10:2311. doi: 10.3389/fmicb.2019.02311. eCollection 2019. Front Microbiol. 2019. PMID: 31649650 Free PMC article.
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.
Furukawa T, van Rhijn N, Fraczek M, Gsaller F, Davies E, Carr P, Gago S, Fortune-Grant R, Rahman S, Gilsenan JM, Houlder E, Kowalski CH, Raj S, Paul S, Cook P, Parker JE, Kelly S, Cramer RA, Latgé JP, Moye-Rowley S, Bignell E, Bowyer P, Bromley MJ. Furukawa T, et al. Among authors: bignell e. Nat Commun. 2020 Jan 22;11(1):427. doi: 10.1038/s41467-019-14191-1. Nat Commun. 2020. PMID: 31969561 Free PMC article.
Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response.
Sueiro-Olivares M, Scott J, Gago S, Petrovic D, Kouroussis E, Zivanovic J, Yu Y, Strobel M, Cunha C, Thomson D, Fortune-Grant R, Thusek S, Bowyer P, Beilhack A, Carvalho A, Bignell E, Filipovic MR, Amich J. Sueiro-Olivares M, et al. Among authors: bignell e. PLoS Biol. 2021 Jun 1;19(6):e3001247. doi: 10.1371/journal.pbio.3001247. eCollection 2021 Jun. PLoS Biol. 2021. PMID: 34061822 Free PMC article.
Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms.
Rahman S, van Rhijn N, Papastamoulis P, Thomson DD, Carter Z, Fortune-Grant R, Rattray M, Bromley MJ, Bignell E. Rahman S, et al. Among authors: bignell e. Front Cell Infect Microbiol. 2022 Jul 28;12:907519. doi: 10.3389/fcimb.2022.907519. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35982778 Free PMC article.
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