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A cross-platform approach identifies genetic regulators of human metabolism and health.
Lotta LA, Pietzner M, Stewart ID, Wittemans LBL, Li C, Bonelli R, Raffler J, Biggs EK, Oliver-Williams C, Auyeung VPW, Luan J, Wheeler E, Paige E, Surendran P, Michelotti GA, Scott RA, Burgess S, Zuber V, Sanderson E, Koulman A, Imamura F, Forouhi NG, Khaw KT; MacTel Consortium; Griffin JL, Wood AM, Kastenmüller G, Danesh J, Butterworth AS, Gribble FM, Reimann F, Bahlo M, Fauman E, Wareham NJ, Langenberg C. Lotta LA, et al. Among authors: biggs ek. Nat Genet. 2021 Jan;53(1):54-64. doi: 10.1038/s41588-020-00751-5. Epub 2021 Jan 7. Nat Genet. 2021. PMID: 33414548 Free PMC article.
Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.
Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. Adriaenssens AE, et al. Among authors: biggs ek. Cell Metab. 2019 Nov 5;30(5):987-996.e6. doi: 10.1016/j.cmet.2019.07.013. Epub 2019 Aug 22. Cell Metab. 2019. PMID: 31447324 Free PMC article.
Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery.
Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM. Larraufie P, et al. Among authors: biggs ek. Cell Rep. 2019 Feb 5;26(6):1399-1408.e6. doi: 10.1016/j.celrep.2019.01.047. Cell Rep. 2019. PMID: 30726726 Free PMC article. Clinical Trial.
Itraconazole targets cell cycle heterogeneity in colorectal cancer.
Buczacki SJA, Popova S, Biggs E, Koukorava C, Buzzelli J, Vermeulen L, Hazelwood L, Francies H, Garnett MJ, Winton DJ. Buczacki SJA, et al. J Exp Med. 2018 Jul 2;215(7):1891-1912. doi: 10.1084/jem.20171385. Epub 2018 May 31. J Exp Med. 2018. PMID: 29853607 Free PMC article.