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Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer.
Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A, Drechsel N, Charneco C, Davis S, Bellora N, Gallardo F, López-Arribillaga E, Asensio-Juan E, Rodilla V, González J, Iglesias M, Shih V, Mar Albà M, Di Croce L, Hoffmann A, Miyamoto S, Villà-Freixa J, López-Bigas N, Keyes WM, Domínguez M, Bigas A, Espinosa L. Mulero MC, et al. Among authors: bigas a. Cancer Cell. 2013 Aug 12;24(2):151-66. doi: 10.1016/j.ccr.2013.06.003. Epub 2013 Jul 11. Cancer Cell. 2013. PMID: 23850221 Free PMC article.
Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation.
Porcheri C, Golan O, Calero-Nieto FJ, Thambyrajah R, Ruiz-Herguido C, Wang X, Catto F, Guillén Y, Sinha R, González J, Kinston SJ, Mariani SA, Maglitto A, Vink CS, Dzierzak E, Charbord P, Göttgens B, Espinosa L, Sprinzak D, Bigas A. Porcheri C, et al. Among authors: bigas a. EMBO J. 2020 Apr 15;39(8):e104270. doi: 10.15252/embj.2019104270. Epub 2020 Mar 9. EMBO J. 2020. PMID: 32149421 Free PMC article.
Notch Signaling in HSC Emergence: When, Why and How.
Thambyrajah R, Bigas A. Thambyrajah R, et al. Among authors: bigas a. Cells. 2022 Jan 21;11(3):358. doi: 10.3390/cells11030358. Cells. 2022. PMID: 35159166 Free PMC article. Review.
β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia.
García-Hernández V, Arambilet D, Guillén Y, Lobo-Jarne T, Maqueda M, Gekas C, González J, Iglesias A, Vega-García N, Sentís I, Trincado JL, Márquez-López I, Heyn H, Camós M, Espinosa L, Bigas A. García-Hernández V, et al. Among authors: bigas a. EMBO Mol Med. 2023 Feb 8;15(2):e16554. doi: 10.15252/emmm.202216554. Epub 2023 Jan 4. EMBO Mol Med. 2023. PMID: 36597789 Free PMC article.
Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate.
Thambyrajah R, Maqueda M, Neo WH, Imbach K, Guillén Y, Grases D, Fadlullah Z, Gambera S, Matteini F, Wang X, Calero-Nieto FJ, Esteller M, Florian MC, Porta E, Benedito R, Göttgens B, Lacaud G, Espinosa L, Bigas A. Thambyrajah R, et al. Among authors: bigas a. Nat Commun. 2024 Feb 21;15(1):1604. doi: 10.1038/s41467-024-45716-y. Nat Commun. 2024. PMID: 38383534 Free PMC article.
Hematopoietic stem cells: to be or Notch to be.
Bigas A, Espinosa L. Bigas A, et al. Blood. 2012 Apr 5;119(14):3226-35. doi: 10.1182/blood-2011-10-355826. Epub 2012 Feb 3. Blood. 2012. PMID: 22308291 Free article. Review.
The Notch pathway in hematopoietic stem cells.
Bigas A, D'Altri T, Espinosa L. Bigas A, et al. Curr Top Microbiol Immunol. 2012;360:1-18. doi: 10.1007/82_2012_229. Curr Top Microbiol Immunol. 2012. PMID: 22692832 Review.
121 results