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Methylglyoxal evokes pain by stimulating TRPA1.
Andersson DA, Gentry C, Light E, Vastani N, Vallortigara J, Bierhaus A, Fleming T, Bevan S. Andersson DA, et al. Among authors: bierhaus a. PLoS One. 2013 Oct 22;8(10):e77986. doi: 10.1371/journal.pone.0077986. eCollection 2013. PLoS One. 2013. PMID: 24167592 Free PMC article.
Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies.
Eberhardt MJ, Filipovic MR, Leffler A, de la Roche J, Kistner K, Fischer MJ, Fleming T, Zimmermann K, Ivanovic-Burmazovic I, Nawroth PP, Bierhaus A, Reeh PW, Sauer SK. Eberhardt MJ, et al. Among authors: bierhaus a. J Biol Chem. 2012 Aug 17;287(34):28291-306. doi: 10.1074/jbc.M111.328674. Epub 2012 Jun 27. J Biol Chem. 2012. PMID: 22740698 Free PMC article.
Aging-dependent reduction in glyoxalase 1 delays wound healing.
Fleming TH, Theilen TM, Masania J, Wunderle M, Karimi J, Vittas S, Bernauer R, Bierhaus A, Rabbani N, Thornalley PJ, Kroll J, Tyedmers J, Nawrotzki R, Herzig S, Brownlee M, Nawroth PP. Fleming TH, et al. Among authors: bierhaus a. Gerontology. 2013;59(5):427-37. doi: 10.1159/000351628. Epub 2013 Jun 22. Gerontology. 2013. PMID: 23797271
Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.
Bierhaus A, Fleming T, Stoyanov S, Leffler A, Babes A, Neacsu C, Sauer SK, Eberhardt M, Schnölzer M, Lasitschka F, Neuhuber WL, Kichko TI, Konrade I, Elvert R, Mier W, Pirags V, Lukic IK, Morcos M, Dehmer T, Rabbani N, Thornalley PJ, Edelstein D, Nau C, Forbes J, Humpert PM, Schwaninger M, Ziegler D, Stern DM, Cooper ME, Haberkorn U, Brownlee M, Reeh PW, Nawroth PP. Bierhaus A, et al. Nat Med. 2012 Jun;18(6):926-33. doi: 10.1038/nm.2750. Nat Med. 2012. PMID: 22581285
C332C genotype of glyoxalase 1 and its association with late diabetic complications.
Groener JB, Reismann P, Fleming T, Kalscheuer H, Lehnhoff D, Hamann A, Roser P, Bierhaus A, Nawroth PP, Rudofsky G. Groener JB, et al. Among authors: bierhaus a. Exp Clin Endocrinol Diabetes. 2013 Jul;121(7):436-9. doi: 10.1055/s-0033-1345124. Epub 2013 Jun 17. Exp Clin Endocrinol Diabetes. 2013. PMID: 23775136 Clinical Trial.
daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans.
Mendler M, Schlotterer A, Ibrahim Y, Kukudov G, Fleming T, Bierhaus A, Riedinger C, Schwenger V, Herzig S, Hecker M, Tyedmers J, Nawroth PP, Morcos M. Mendler M, et al. Among authors: bierhaus a. Diabetologia. 2015 Feb;58(2):393-401. doi: 10.1007/s00125-014-3415-5. Epub 2014 Oct 17. Diabetologia. 2015. PMID: 25322843
249 results