Bien-Ly N - Search Results

1

Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.

Litvinchuk A, Suh JH, Guo JL, Lin K, Davis SS, Bien-Ly N, Tycksen E, Tabor GT, Remolina Serrano J, Manis M, Bao X, Lee C, Bosch M, Perez EJ, Yuede CM, Cashikar AG, Ulrich JD, Di Paolo G, Holtzman DM. Litvinchuk A, et al. Among authors: bien ly n. Neuron. 2024 Feb 7;112(3):384-403.e8. doi: 10.1016/j.neuron.2023.10.023. Epub 2023 Nov 22. Neuron. 2024. PMID: 37995685

2

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.

Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, Henne K, Leyns CE, Gallardo G, Ulrich JD, Sullivan PM, Lerner EP, Hudry E, Sweeney ZK, Dennis MS, Hyman BT, Watts RJ, Holtzman DM. Liao F, et al. Among authors: bien ly n. J Clin Invest. 2018 May 1;128(5):2144-2155. doi: 10.1172/JCI96429. Epub 2018 Mar 30. J Clin Invest. 2018. PMID: 29600961 Free PMC article.

3

APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function.

Xiong M, Jiang H, Serrano JR, Gonzales ER, Wang C, Gratuze M, Hoyle R, Bien-Ly N, Silverman AP, Sullivan PM, Watts RJ, Ulrich JD, Zipfel GJ, Holtzman DM. Xiong M, et al. Among authors: bien ly n. Sci Transl Med. 2021 Feb 17;13(581):eabd7522. doi: 10.1126/scitranslmed.abd7522. Sci Transl Med. 2021. PMID: 33597265 Free PMC article.

4

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.

Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L. Palop JJ, et al. Neuron. 2007 Sep 6;55(5):697-711. doi: 10.1016/j.neuron.2007.07.025. Neuron. 2007. PMID: 17785178 Free PMC article.

5

Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies.

Bien-Ly N, Boswell CA, Jeet S, Beach TG, Hoyte K, Luk W, Shihadeh V, Ulufatu S, Foreman O, Lu Y, DeVoss J, van der Brug M, Watts RJ. Bien-Ly N, et al. Neuron. 2015 Oct 21;88(2):289-97. doi: 10.1016/j.neuron.2015.09.036. Neuron. 2015. PMID: 26494278 Free article.

6

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.

Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y. Bien-Ly N, et al. J Neurosci. 2012 Apr 4;32(14):4803-11. doi: 10.1523/JNEUROSCI.0033-12.2012. J Neurosci. 2012. PMID: 22492035 Free PMC article.

7

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.

Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, Kirkpatrick DS, Ernst JA, Chih B, Dennis MS, Watts RJ. Zuchero YJ, et al. Among authors: bien ly n. Neuron. 2016 Jan 6;89(1):70-82. doi: 10.1016/j.neuron.2015.11.024. Epub 2015 Dec 10. Neuron. 2016. PMID: 26687840 Free article.

8

Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.

Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y. Andrews-Zwilling Y, et al. J Neurosci. 2010 Oct 13;30(41):13707-17. doi: 10.1523/JNEUROSCI.4040-10.2010. J Neurosci. 2010. PMID: 20943911 Free PMC article.

9

GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.

Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y. Li G, et al. Cell Stem Cell. 2009 Dec 4;5(6):634-45. doi: 10.1016/j.stem.2009.10.015. Cell Stem Cell. 2009. PMID: 19951691 Free PMC article.

10

C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.

Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y. Bien-Ly N, et al. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4236-41. doi: 10.1073/pnas.1018381108. Epub 2011 Feb 22. Proc Natl Acad Sci U S A. 2011. PMID: 21368138 Free PMC article.

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