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Chronic nSMase inhibition suppresses neuronal exosome spreading and sex-specifically attenuates amyloid pathology in APP knock-in Alzheimer's disease mice.
Mowry FE, Espejo-Porras F, Jin S, Quadri Z, Wu L, Bertolio M, Jarvis R, Reynolds C, Alananzeh R, Bieberich E, Yang Y. Mowry FE, et al. Among authors: bieberich e. Neurobiol Dis. 2023 Aug;184:106213. doi: 10.1016/j.nbd.2023.106213. Epub 2023 Jun 25. Neurobiol Dis. 2023. PMID: 37364689 Free PMC article.
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse.
Crivelli SM, Quadri Z, Vekaria HJ, Zhu Z, Tripathi P, Elsherbini A, Zhang L, Sullivan PG, Bieberich E. Crivelli SM, et al. Among authors: bieberich e. Acta Neuropathol Commun. 2023 Aug 21;11(1):135. doi: 10.1186/s40478-023-01633-7. Acta Neuropathol Commun. 2023. PMID: 37605262 Free PMC article.
Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking.
Palladino END, Bernas T, Green CD, Weigel C, Singh SK, Senkal CE, Martello A, Kennelly JP, Bieberich E, Tontonoz P, Ford DA, Milstien S, Eden ER, Spiegel S. Palladino END, et al. Among authors: bieberich e. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2204396119. doi: 10.1073/pnas.2204396119. Epub 2022 Sep 19. Proc Natl Acad Sci U S A. 2022. PMID: 36122218 Free PMC article.
FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing APOE4.
Crivelli SM, Luo Q, Kruining DV, Giovagnoni C, Mané-Damas M, den Hoedt S, Berkes D, De Vries HE, Mulder MT, Walter J, Waelkens E, Derua R, Swinnen JV, Dehairs J, Wijnands EPM, Bieberich E, Losen M, Martinez-Martinez P. Crivelli SM, et al. Among authors: bieberich e. Biomed Pharmacother. 2022 Aug;152:113240. doi: 10.1016/j.biopha.2022.113240. Epub 2022 Jun 9. Biomed Pharmacother. 2022. PMID: 35689862 Free article.
114 results