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Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells.
Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova-Lamperti E, Kumar D, Zhang Z, Teague H, West EE, Vannella KM, Ramos-Benitez MJ, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz DM, Portilla D, Chertow DS, John S, Lavender P, Kemper C, Lombardi G, Mehta NN, Cooper N, Lionakis MS, Laurence A, Kazemian M, Afzali B. Chauss D, et al. Among authors: bibby j. Nat Immunol. 2022 Jan;23(1):62-74. doi: 10.1038/s41590-021-01080-3. Epub 2021 Nov 11. Nat Immunol. 2022. PMID: 34764490 Free PMC article.
The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.
Perucha E, Melchiotti R, Bibby JA, Wu W, Frederiksen KS, Roberts CA, Hall Z, LeFriec G, Robertson KA, Lavender P, Gerwien JG, Taams LS, Griffin JL, de Rinaldis E, van Baarsen LGM, Kemper C, Ghazal P, Cope AP. Perucha E, et al. Nat Commun. 2019 Jan 30;10(1):498. doi: 10.1038/s41467-019-08332-9. Nat Commun. 2019. PMID: 30700717 Free PMC article.
SARS-CoV2 drives JAK1/2-dependent local and systemic complement hyper-activation.
Yan B, Freiwald T, Chauss D, Wang L, West E, Bibby J, Olson M, Kordasti S, Portilla D, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M. Yan B, et al. Among authors: bibby j. Res Sq [Preprint]. 2020 Jun 9:rs.3.rs-33390. doi: 10.21203/rs.3.rs-33390/v1. Res Sq. 2020. PMID: 32702726 Free PMC article. Updated. Preprint.
An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19.
McGregor R, Chauss D, Freiwald T, Yan B, Wang L, Nova-Lamperti E, Zhang Z, Teague H, West EE, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz D, Portilla D, John S, Lavender P, Lionakis MS, Mehta NN, Kemper C, Cooper N, Lombardi G, Laurence A, Kazemian M, Afzali B. McGregor R, et al. Among authors: bibby j. bioRxiv [Preprint]. 2020 Jul 19:2020.07.18.210161. doi: 10.1101/2020.07.18.210161. bioRxiv. 2020. PMID: 32743590 Free PMC article. Preprint.
Proteomic, biomechanical and functional analyses define neutrophil heterogeneity in systemic lupus erythematosus.
Bashant KR, Aponte AM, Randazzo D, Rezvan Sangsari P, Wood AJ, Bibby JA, West EE, Vassallo A, Manna ZG, Playford MP, Jordan N, Hasni S, Gucek M, Kemper C, Conway Morris A, Morgan NY, Toepfner N, Guck J, Mehta NN, Chilvers ER, Summers C, Kaplan MJ. Bashant KR, et al. Among authors: bibby ja. Ann Rheum Dis. 2021 Feb;80(2):209-218. doi: 10.1136/annrheumdis-2020-218338. Epub 2020 Sep 28. Ann Rheum Dis. 2021. PMID: 32988843 Free PMC article.
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.
Yan B, Freiwald T, Chauss D, Wang L, West E, Mirabelli C, Zhang CJ, Nichols EM, Malik N, Gregory R, Bantscheff M, Ghidelli-Disse S, Kolev M, Frum T, Spence JR, Sexton JZ, Alysandratos KD, Kotton DN, Pittaluga S, Bibby J, Niyonzima N, Olson MR, Kordasti S, Portilla D, Wobus CE, Laurence A, Lionakis MS, Kemper C, Afzali B, Kazemian M. Yan B, et al. Among authors: bibby j. Sci Immunol. 2021 Apr 7;6(58):eabg0833. doi: 10.1126/sciimmunol.abg0833. Sci Immunol. 2021. PMID: 33827897 Free PMC article.
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation.
Niyonzima N, Rahman J, Kunz N, West EE, Freiwald T, Desai JV, Merle NS, Gidon A, Sporsheim B, Lionakis MS, Evensen K, Lindberg B, Skagen K, Skjelland M, Singh P, Haug M, Ruseva MM, Kolev M, Bibby J, Marshall O, O'Brien B, Deeks N, Afzali B, Clark RJ, Woodruff TM, Pryor M, Yang ZH, Remaley AT, Mollnes TE, Hewitt SM, Yan B, Kazemian M, Kiss MG, Binder CJ, Halvorsen B, Espevik T, Kemper C. Niyonzima N, et al. Among authors: bibby j. Sci Immunol. 2021 Dec 24;6(66):eabf2489. doi: 10.1126/sciimmunol.abf2489. Epub 2021 Dec 24. Sci Immunol. 2021. PMID: 34932384 Free PMC article.
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection.
West EE, Merle NS, Kamiński MM, Palacios G, Kumar D, Wang L, Bibby JA, Overdahl K, Jarmusch AK, Freeley S, Lee DY, Thompson JW, Yu ZX, Taylor N, Sitbon M, Green DR, Bohrer A, Mayer-Barber KD, Afzali B, Kazemian M, Scholl-Buergi S, Karall D, Huemer M, Kemper C. West EE, et al. Among authors: bibby ja. Immunity. 2023 Sep 12;56(9):2036-2053.e12. doi: 10.1016/j.immuni.2023.07.014. Epub 2023 Aug 11. Immunity. 2023. PMID: 37572656 Free PMC article.
75 results