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A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.
Massignan T, Cimini S, Stincardini C, Cerovic M, Vanni I, Elezgarai SR, Moreno J, Stravalaci M, Negro A, Sangiovanni V, Restelli E, Riccardi G, Gobbi M, Castilla J, Borsello T, Nonno R, Biasini E. Massignan T, et al. Among authors: biasini e. Sci Rep. 2016 Mar 15;6:23180. doi: 10.1038/srep23180. Sci Rep. 2016. PMID: 26976106 Free PMC article.
A Small-Molecule Inhibitor of Prion Replication and Mutant Prion Protein Toxicity.
Massignan T, Sangiovanni V, Biggi S, Stincardini C, Elezgarai SR, Maietta G, Andreev IA, Ratmanova NK, Belov DS, Lukyanenko ER, Belov GM, Barreca ML, Altieri A, Kurkin AV, Biasini E. Massignan T, et al. Among authors: biasini e. ChemMedChem. 2017 Aug 22;12(16):1286-1292. doi: 10.1002/cmdc.201700302. Epub 2017 Aug 1. ChemMedChem. 2017. PMID: 28722340
An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.
Stincardini C, Massignan T, Biggi S, Elezgarai SR, Sangiovanni V, Vanni I, Pancher M, Adami V, Moreno J, Stravalaci M, Maietta G, Gobbi M, Negro A, Requena JR, Castilla J, Nonno R, Biasini E. Stincardini C, et al. Among authors: biasini e. PLoS One. 2017 Aug 7;12(8):e0182589. doi: 10.1371/journal.pone.0182589. eCollection 2017. PLoS One. 2017. PMID: 28787011 Free PMC article.
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors.
Manzoni L, Zucal C, Maio DD, D'Agostino VG, Thongon N, Bonomo I, Lal P, Miceli M, Baj V, Brambilla M, Cerofolini L, Elezgarai S, Biasini E, Luchinat C, Novellino E, Fragai M, Marinelli L, Provenzani A, Seneci P. Manzoni L, et al. Among authors: biasini e. J Med Chem. 2018 Feb 22;61(4):1483-1498. doi: 10.1021/acs.jmedchem.7b01176. Epub 2018 Jan 31. J Med Chem. 2018. PMID: 29313684
Regulation of HuR structure and function by dihydrotanshinone-I.
Lal P, Cerofolini L, D'Agostino VG, Zucal C, Fuccio C, Bonomo I, Dassi E, Giuntini S, Di Maio D, Vishwakarma V, Preet R, Williams SN, Fairlamb MS, Munk R, Lehrmann E, Abdelmohsen K, Elezgarai SR, Luchinat C, Novellino E, Quattrone A, Biasini E, Manzoni L, Gorospe M, Dixon DA, Seneci P, Marinelli L, Fragai M, Provenzani A. Lal P, et al. Among authors: biasini e. Nucleic Acids Res. 2017 Sep 19;45(16):9514-9527. doi: 10.1093/nar/gkx623. Nucleic Acids Res. 2017. PMID: 28934484 Free PMC article.
116 results