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Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD.
Muthukaman N, Deshmukh S, Tondlekar S, Tambe M, Pisal D, Sarode N, Mhatre S, Chakraborti S, Shah D, Bhosale VM, Kulkarni A, Mahat MYA, Jadhav SB, Gudi GS, Khairatkar-Joshi N, Gharat LA. Muthukaman N, et al. Among authors: bhosale vm. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3766-3773. doi: 10.1016/j.bmcl.2018.10.012. Epub 2018 Oct 10. Bioorg Med Chem Lett. 2018. PMID: 30340896
Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists.
Chaudhari SS, Kadam AB, Khairatkar-Joshi N, Mukhopadhyay I, Karnik PV, Raghuram A, Rao SS, Vaiyapuri TS, Wale DP, Bhosale VM, Gudi GS, Sangana RR, Thomas A. Chaudhari SS, et al. Among authors: bhosale vm. Bioorg Med Chem. 2013 Nov 1;21(21):6542-53. doi: 10.1016/j.bmc.2013.08.031. Epub 2013 Aug 29. Bioorg Med Chem. 2013. PMID: 24055075
An inhibitor of RORγ for chronic pulmonary obstructive disease treatment.
Desai H, Marathe M, Potdar V, Tiwari P, Joshi A, Kadam SR, Joshi AR, Kulkarni A, Bhosale V, Hadambar A, Lodhiya B, Udupa V, Behera D, Chaudhari SS, Das S, Bajpai M, Gowda N, Iyer PS. Desai H, et al. Sci Rep. 2022 May 24;12(1):8744. doi: 10.1038/s41598-022-12251-z. Sci Rep. 2022. PMID: 35610240 Free PMC article.