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Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.
Abuhammad A, Fullam E, Lowe ED, Staunton D, Kawamura A, Westwood IM, Bhakta S, Garner AC, Wilson DL, Seden PT, Davies SG, Russell AJ, Garman EF, Sim E. Abuhammad A, et al. Among authors: bhakta s. PLoS One. 2012;7(12):e52790. doi: 10.1371/journal.pone.0052790. Epub 2012 Dec 28. PLoS One. 2012. PMID: 23285185 Free PMC article.
Arylamine N-acetyltransferases in mycobacteria.
Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I, Krylova A, Lack N, Noble M. Sim E, et al. Among authors: bhakta s. Curr Drug Metab. 2008 Jul;9(6):510-9. doi: 10.2174/138920008784892100. Curr Drug Metab. 2008. PMID: 18680471 Free PMC article. Review.
Exploration of piperidinols as potential antitubercular agents.
Abuhammad A, Fullam E, Bhakta S, Russell AJ, Morris GM, Finn PW, Sim E. Abuhammad A, et al. Among authors: bhakta s. Molecules. 2014 Oct 10;19(10):16274-90. doi: 10.3390/molecules191016274. Molecules. 2014. PMID: 25310152 Free PMC article.
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.
Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E. Ryan A, et al. Among authors: bhakta s. Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9. Br J Pharmacol. 2017. PMID: 28380256 Free PMC article.
328 results