Bhagwat AS - Search Results

1

An extended APOBEC3A mutation signature in cancer.

Langenbucher A, Bowen D, Sakhtemani R, Bournique E, Wise JF, Zou L, Bhagwat AS, Buisson R, Lawrence MS. Langenbucher A, et al. Among authors: bhagwat as. Nat Commun. 2021 Mar 11;12(1):1602. doi: 10.1038/s41467-021-21891-0. Nat Commun. 2021. PMID: 33707442 Free PMC article.

2

Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G.

Wijesinghe P, Bhagwat AS. Wijesinghe P, et al. Among authors: bhagwat as. Nucleic Acids Res. 2012 Oct;40(18):9206-17. doi: 10.1093/nar/gks685. Epub 2012 Jul 13. Nucleic Acids Res. 2012. PMID: 22798497 Free PMC article.

3

APOBEC3A damages the cellular genome during DNA replication.

Green AM, Landry S, Budagyan K, Avgousti DC, Shalhout S, Bhagwat AS, Weitzman MD. Green AM, et al. Among authors: bhagwat as. Cell Cycle. 2016;15(7):998-1008. doi: 10.1080/15384101.2016.1152426. Cell Cycle. 2016. PMID: 26918916 Free PMC article.

4

A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers.

Wei S, Perera MLW, Sakhtemani R, Bhagwat AS. Wei S, et al. Among authors: bhagwat as. PLoS One. 2017 Sep 19;12(9):e0185010. doi: 10.1371/journal.pone.0185010. eCollection 2017. PLoS One. 2017. PMID: 28926604 Free PMC article.

5

A Tumor-Promoting Phorbol Ester Causes a Large Increase in APOBEC3A Expression and a Moderate Increase in APOBEC3B Expression in a Normal Human Keratinocyte Cell Line without Increasing Genomic Uracils.

Siriwardena SU, Perera MLW, Senevirathne V, Stewart J, Bhagwat AS. Siriwardena SU, et al. Among authors: bhagwat as. Mol Cell Biol. 2018 Dec 11;39(1):e00238-18. doi: 10.1128/MCB.00238-18. Print 2019 Jan 1. Mol Cell Biol. 2018. PMID: 30348839 Free PMC article.

6

Genome-wide mapping of regions preferentially targeted by the human DNA-cytosine deaminase APOBEC3A using uracil-DNA pulldown and sequencing.

Sakhtemani R, Senevirathne V, Stewart J, Perera MLW, Pique-Regi R, Lawrence MS, Bhagwat AS. Sakhtemani R, et al. Among authors: bhagwat as. J Biol Chem. 2019 Oct 11;294(41):15037-15051. doi: 10.1074/jbc.RA119.008053. Epub 2019 Aug 19. J Biol Chem. 2019. PMID: 31431505 Free PMC article.

7

Human Herpes Simplex Virus-1 depletes APOBEC3A from nuclei.

Stewart JA, Holland TC, Bhagwat AS. Stewart JA, et al. Among authors: bhagwat as. Virology. 2019 Nov;537:104-109. doi: 10.1016/j.virol.2019.08.012. Epub 2019 Aug 13. Virology. 2019. PMID: 31493648 Free PMC article.

8

Visualization of uracils created by APOBEC3A using UdgX shows colocalization with RPA at stalled replication forks.

Stewart JA, Schauer G, Bhagwat AS. Stewart JA, et al. Among authors: bhagwat as. Nucleic Acids Res. 2020 Nov 18;48(20):e118. doi: 10.1093/nar/gkaa845. Nucleic Acids Res. 2020. PMID: 33074285 Free PMC article.

9

Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops.

Sakhtemani R, Perera MLW, Hübschmann D, Siebert R, Lawrence MS, Bhagwat AS. Sakhtemani R, et al. Among authors: bhagwat as. Nucleic Acids Res. 2022 May 20;50(9):5145-5157. doi: 10.1093/nar/gkac296. Nucleic Acids Res. 2022. PMID: 35524550 Free PMC article.

10

Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.

Butt Y, Sakhtemani R, Mohamad-Ramshan R, Lawrence MS, Bhagwat AS. Butt Y, et al. Among authors: bhagwat as. bioRxiv [Preprint]. 2023 Aug 2:2023.08.01.551518. doi: 10.1101/2023.08.01.551518. bioRxiv. 2023. PMID: 37577595 Free PMC article. Updated. Preprint.

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