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DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.
Shao Z, Flynn RA, Crowe JL, Zhu Y, Liang J, Jiang W, Aryan F, Aoude P, Bertozzi CR, Estes VM, Lee BJ, Bhagat G, Zha S, Calo E. Shao Z, et al. Among authors: bhagat g. Nature. 2020 Mar;579(7798):291-296. doi: 10.1038/s41586-020-2041-2. Epub 2020 Feb 26. Nature. 2020. PMID: 32103174 Free PMC article.
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zúñiga-Pflücker JC, Dominguez M, Ferrando AA. Palomero T, et al. Among authors: bhagat g. Nat Med. 2007 Oct;13(10):1203-10. doi: 10.1038/nm1636. Epub 2007 Sep 16. Nat Med. 2007. PMID: 17873882 Free PMC article.
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts.
Kode A, Manavalan JS, Mosialou I, Bhagat G, Rathinam CV, Luo N, Khiabanian H, Lee A, Murty VV, Friedman R, Brum A, Park D, Galili N, Mukherjee S, Teruya-Feldstein J, Raza A, Rabadan R, Berman E, Kousteni S. Kode A, et al. Among authors: bhagat g. Nature. 2014 Feb 13;506(7487):240-4. doi: 10.1038/nature12883. Epub 2014 Jan 15. Nature. 2014. PMID: 24429522 Free PMC article.
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Fernández ÁF, Sebti S, Wei Y, Zou Z, Shi M, McMillan KL, He C, Ting T, Liu Y, Chiang WC, Marciano DK, Schiattarella GG, Bhagat G, Moe OW, Hu MC, Levine B. Fernández ÁF, et al. Among authors: bhagat g. Nature. 2018 Jun;558(7708):136-140. doi: 10.1038/s41586-018-0162-7. Epub 2018 May 30. Nature. 2018. PMID: 29849149 Free PMC article.
Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression.
Leeman-Neill RJ, Song D, Bizarro J, Wacheul L, Rothschild G, Singh S, Yang Y, Sarode AY, Gollapalli K, Wu L, Zhang W, Chen Y, Lauring MC, Whisenant DE, Bhavsar S, Lim J, Swerdlow SH, Bhagat G, Zhao Q, Berchowitz LE, Lafontaine DLJ, Wang J, Basu U. Leeman-Neill RJ, et al. Among authors: bhagat g. Nat Genet. 2023 Dec;55(12):2160-2174. doi: 10.1038/s41588-023-01561-1. Epub 2023 Dec 4. Nat Genet. 2023. PMID: 38049665 Free PMC article.
AID is required for germinal center-derived lymphomagenesis.
Pasqualucci L, Bhagat G, Jankovic M, Compagno M, Smith P, Muramatsu M, Honjo T, Morse HC 3rd, Nussenzweig MC, Dalla-Favera R. Pasqualucci L, et al. Among authors: bhagat g. Nat Genet. 2008 Jan;40(1):108-12. doi: 10.1038/ng.2007.35. Epub 2007 Dec 9. Nat Genet. 2008. PMID: 18066064
339 results