Beyl S - Search Results

1

Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters.

Kalaba P, Ilić M, Aher NY, Dragačević V, Wieder M, Zehl M, Wackerlig J, Beyl S, Sartori SB, Ebner K, Roller A, Lukic N, Beryozkina T, Gonzalez ERP, Neill P, Khan JA, Bakulev V, Leban JJ, Hering S, Pifl C, Singewald N, Lubec J, Urban E, Sitte HH, Langer T, Lubec G. Kalaba P, et al. Among authors: beyl s. J Med Chem. 2020 Jan 9;63(1):391-417. doi: 10.1021/acs.jmedchem.9b01938. Epub 2019 Dec 30. J Med Chem. 2020. PMID: 31841637

2

Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder.

Hohaus A, Beyl S, Kudrnac M, Berjukow S, Timin EN, Marksteiner R, Maw MA, Hering S. Hohaus A, et al. Among authors: beyl s. J Biol Chem. 2005 Nov 18;280(46):38471-7. doi: 10.1074/jbc.M507013200. Epub 2005 Sep 12. J Biol Chem. 2005. PMID: 16157588 Free PMC article.

3

Probing the architecture of an L-type calcium channel with a charged phenylalkylamine: evidence for a widely open pore and drug trapping.

Beyl S, Timin EN, Hohaus A, Stary A, Kudrnac M, Guy RH, Hering S. Beyl S, et al. J Biol Chem. 2007 Feb 9;282(6):3864-70. doi: 10.1074/jbc.M609153200. Epub 2006 Nov 30. J Biol Chem. 2007. PMID: 17138559 Free PMC article.

4

Molecular dynamics and mutational analysis of a channelopathy mutation in the IIS6 helix of Ca V 1.2.

Stary A, Kudrnac M, Beyl S, Hohaus A, Timin EN, Wolschann P, Guy HR, Hering S. Stary A, et al. Among authors: beyl s. Channels (Austin). 2008 May-Jun;2(3):216-23. doi: 10.4161/chan.2.3.6160. Epub 2008 May 18. Channels (Austin). 2008. PMID: 18836301 Free PMC article.

5

Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2.

Kudrnac M, Beyl S, Hohaus A, Stary A, Peterbauer T, Timin E, Hering S. Kudrnac M, et al. Among authors: beyl s. J Biol Chem. 2009 May 1;284(18):12276-84. doi: 10.1074/jbc.M808402200. Epub 2009 Mar 5. J Biol Chem. 2009. PMID: 19265197 Free PMC article.

Significant effects are induced by either proline or threonine substitutions in the lower third of segment IIS6 ("bundle crossing region"), where S6 segments are likely to seal the channel in the closed conformation (Hohaus, A., Beyl, S., Kudrnac, M., Berjukow, S …

Significant effects are induced by either proline or threonine substitutions in the lower third of segment IIS6 ("bundle crossing region"), …

6

Different pathways for activation and deactivation in CaV1.2: a minimal gating model.

Beyl S, Kügler P, Kudrnac M, Hohaus A, Hering S, Timin E. Beyl S, et al. J Gen Physiol. 2009 Sep;134(3):231-41; S1-2. doi: 10.1085/jgp.200910272. Epub 2009 Aug 17. J Gen Physiol. 2009. PMID: 19687230 Free PMC article.

7

Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating.

Karmazinova M, Beyl S, Stary-Weinzinger A, Suwattanasophon C, Klugbauer N, Hering S, Lacinova L. Karmazinova M, et al. Among authors: beyl s. Pflugers Arch. 2010 Nov;460(6):1015-28. doi: 10.1007/s00424-010-0874-5. Epub 2010 Sep 9. Pflugers Arch. 2010. PMID: 20827487

8

Physicochemical properties of pore residues predict activation gating of Ca V1.2: a correlation mutation analysis.

Beyl S, Depil K, Hohaus A, Stary-Weinzinger A, Timin E, Shabbir W, Kudrnac M, Hering S. Beyl S, et al. Pflugers Arch. 2011 Jan;461(1):53-63. doi: 10.1007/s00424-010-0885-2. Epub 2010 Oct 7. Pflugers Arch. 2011. PMID: 20924598 Free PMC article.

9

Timothy mutation disrupts the link between activation and inactivation in Ca(V)1.2 protein.

Depil K, Beyl S, Stary-Weinzinger A, Hohaus A, Timin E, Hering S. Depil K, et al. Among authors: beyl s. J Biol Chem. 2011 Sep 9;286(36):31557-64. doi: 10.1074/jbc.M111.255273. Epub 2011 Jun 17. J Biol Chem. 2011. PMID: 21685391 Free PMC article.

10

Neutralisation of a single voltage sensor affects gating determinants in all four pore-forming S6 segments of Ca(V)1.2: a cooperative gating model.

Beyl S, Depil K, Hohaus A, Stary-Weinzinger A, Linder T, Timin E, Hering S. Beyl S, et al. Pflugers Arch. 2012 Oct;464(4):391-401. doi: 10.1007/s00424-012-1144-5. Epub 2012 Sep 2. Pflugers Arch. 2012. PMID: 22941337 Free PMC article.

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