Beukers MW - Search Results

1

Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.

Yamamoto Y, Välitalo PA, Wong YC, Huntjens DR, Proost JH, Vermeulen A, Krauwinkel W, Beukers MW, Kokki H, Kokki M, Danhof M, van Hasselt JGC, de Lange ECM. Yamamoto Y, et al. Among authors: beukers mw. Eur J Pharm Sci. 2018 Jan 15;112:168-179. doi: 10.1016/j.ejps.2017.11.011. Epub 2017 Nov 11. Eur J Pharm Sci. 2018. PMID: 29133240

2

Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model.

Yamamoto Y, Välitalo PA, Huntjens DR, Proost JH, Vermeulen A, Krauwinkel W, Beukers MW, van den Berg DJ, Hartman R, Wong YC, Danhof M, van Hasselt JGC, de Lange ECM. Yamamoto Y, et al. Among authors: beukers mw. CPT Pharmacometrics Syst Pharmacol. 2017 Nov;6(11):765-777. doi: 10.1002/psp4.12250. Epub 2017 Oct 13. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28891201 Free PMC article.

3

Nucleoside transport inhibition and platelet aggregation in human blood: R75231 and its enantiomers, draflazine and R88016.

Beukers MW, Kerkhof CJ, IJzerman AP, Soudijn W. Beukers MW, et al. Eur J Pharmacol. 1994 Jan 1;266(1):57-62. doi: 10.1016/0922-4106(94)90209-7. Eur J Pharmacol. 1994. PMID: 8137884

4

GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor.

Peeters MC, van Westen GJ, Guo D, Wisse LE, Müller CE, Beukers MW, Ijzerman AP. Peeters MC, et al. Among authors: beukers mw. FASEB J. 2011 Feb;25(2):632-43. doi: 10.1096/fj.10-164319. Epub 2010 Oct 28. FASEB J. 2011. PMID: 21030693

5

Allosteric modulators affect the internalization of human adenosine A1 receptors.

Klaasse EC, van den Hout G, Roerink SF, de Grip WJ, Ijzerman AP, Beukers MW. Klaasse EC, et al. Among authors: beukers mw. Eur J Pharmacol. 2005 Oct 17;522(1-3):1-8. doi: 10.1016/j.ejphar.2005.08.052. Epub 2005 Oct 7. Eur J Pharmacol. 2005. PMID: 16214128

6

Structure-affinity relationships of adenosine A2B receptor ligands.

Beukers MW, Meurs I, Ijzerman AP. Beukers MW, et al. Med Res Rev. 2006 Sep;26(5):667-98. doi: 10.1002/med.20069. Med Res Rev. 2006. PMID: 16847822 Review.

7

A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines.

van Veldhoven JP, Chang LC, von Frijtag Drabbe Künzel JK, Mulder-Krieger T, Struensee-Link R, Beukers MW, Brussee J, IJzerman AP. van Veldhoven JP, et al. Among authors: beukers mw. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. doi: 10.1016/j.bmc.2008.01.013. Epub 2008 Jan 12. Bioorg Med Chem. 2008. PMID: 18258439

8

2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.

Mantri M, de Graaf O, van Veldhoven J, Göblyös A, von Frijtag Drabbe Künzel JK, Mulder-Krieger T, Link R, de Vries H, Beukers MW, Brussee J, Ijzerman AP. Mantri M, et al. Among authors: beukers mw. J Med Chem. 2008 Aug 14;51(15):4449-55. doi: 10.1021/jm701594y. Epub 2008 Jul 19. J Med Chem. 2008. PMID: 18637670

9

Techniques: how to boost GPCR mutagenesis studies using yeast.

Beukers MW, Ijzerman AP. Beukers MW, et al. Trends Pharmacol Sci. 2005 Oct;26(10):533-9. doi: 10.1016/j.tips.2005.08.005. Trends Pharmacol Sci. 2005. PMID: 16126284 Review.

10

A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors.

Ye K, Lameijer EW, Beukers MW, Ijzerman AP. Ye K, et al. Among authors: beukers mw. Proteins. 2006 Jun 1;63(4):1018-30. doi: 10.1002/prot.20899. Proteins. 2006. PMID: 16532452

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