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Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Zhang J, Lair C, Roubert C, Amaning K, Barrio MB, Benedetti Y, Cui Z, Xing Z, Li X, Franzblau SG, Baurin N, Bordon-Pallier F, Cantalloube C, Sans S, Silve S, Blanc I, Fraisse L, Rak A, Jenner LB, Yusupova G, Yusupov M, Zhang J, Kaneko T, Yang TJ, Fotouhi N, Nuermberger E, Tyagi S, Betoudji F, Upton A, Sacchettini JC, Lagrange S. Zhang J, et al. Among authors: betoudji f. Cell. 2023 Mar 2;186(5):1013-1025.e24. doi: 10.1016/j.cell.2023.01.043. Epub 2023 Feb 23. Cell. 2023. PMID: 36827973 Free PMC article.
A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.
Locher CP, Jones SM, Hanzelka BL, Perola E, Shoen CM, Cynamon MH, Ngwane AH, Wiid IJ, van Helden PD, Betoudji F, Nuermberger EL, Thomson JA. Locher CP, et al. Among authors: betoudji f. Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65. doi: 10.1128/AAC.04347-14. Epub 2014 Dec 22. Antimicrob Agents Chemother. 2015. PMID: 25534737 Free PMC article.
Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis.
Tasneen R, Betoudji F, Tyagi S, Li SY, Williams K, Converse PJ, Dartois V, Yang T, Mendel CM, Mdluli KE, Nuermberger EL. Tasneen R, et al. Among authors: betoudji f. Antimicrob Agents Chemother. 2015 Oct 26;60(1):270-7. doi: 10.1128/AAC.01691-15. Print 2016 Jan. Antimicrob Agents Chemother. 2015. PMID: 26503656 Free PMC article.
Impact of Clofazimine Dosing on Treatment Shortening of the First-Line Regimen in a Mouse Model of Tuberculosis.
Ammerman NC, Swanson RV, Bautista EM, Almeida DV, Saini V, Omansen TF, Guo H, Chang YS, Li SY, Tapley A, Tasneen R, Tyagi S, Betoudji F, Moodley C, Ngcobo B, Pillay L, Bester LA, Singh SD, Chaisson RE, Nuermberger E, Grosset JH. Ammerman NC, et al. Among authors: betoudji f. Antimicrob Agents Chemother. 2018 Jun 26;62(7):e00636-18. doi: 10.1128/AAC.00636-18. Print 2018 Jul. Antimicrob Agents Chemother. 2018. PMID: 29735562 Free PMC article.
Using Dynamic Oral Dosing of Rifapentine and Rifabutin to Simulate Exposure Profiles of Long-Acting Formulations in a Mouse Model of Tuberculosis Preventive Therapy.
Chang YS, Li SY, Pertinez H, Betoudji F, Lee J, Rannard SP, Owen A, Nuermberger EL, Ammerman NC. Chang YS, et al. Among authors: betoudji f. Antimicrob Agents Chemother. 2023 Jul 18;67(7):e0048123. doi: 10.1128/aac.00481-23. Epub 2023 Jun 14. Antimicrob Agents Chemother. 2023. PMID: 37338374 Free PMC article.
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