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Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors.
Hamann MV, Beschorner N, Vu XK, Hauber I, Lange UC, Traenkle B, Kaiser PD, Foth D, Schneider C, Büning H, Rothbauer U, Hauber J. Hamann MV, et al. Among authors: beschorner n. PLoS One. 2021 Dec 20;16(12):e0261269. doi: 10.1371/journal.pone.0261269. eCollection 2021. PLoS One. 2021. PMID: 34928979 Free PMC article.
Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity.
Karpinski J, Hauber I, Chemnitz J, Schäfer C, Paszkowski-Rogacz M, Chakraborty D, Beschorner N, Hofmann-Sieber H, Lange UC, Grundhoff A, Hackmann K, Schrock E, Abi-Ghanem J, Pisabarro MT, Surendranath V, Schambach A, Lindner C, van Lunzen J, Hauber J, Buchholz F. Karpinski J, et al. Among authors: beschorner n. Nat Biotechnol. 2016 Apr;34(4):401-9. doi: 10.1038/nbt.3467. Epub 2016 Feb 22. Nat Biotechnol. 2016. PMID: 26900663
Preclinical toxicity analyses of lentiviral vectors expressing the HIV-1 LTR-specific designer-recombinase Brec1.
Beschorner N, Künzle P, Voges M, Hauber I, Indenbirken D, Nakel J, Virdi S, Bradtke P, Lory NC, Rothe M, Paszkowski-Rogacz M, Buchholz F, Grundhoff A, Schambach A, Thirion C, Mittrücker HW, Schulze Zur Wiesch J, Hauber J, Chemnitz J. Beschorner N, et al. PLoS One. 2024 Mar 8;19(3):e0298542. doi: 10.1371/journal.pone.0298542. eCollection 2024. PLoS One. 2024. PMID: 38457474 Free PMC article.
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
Stroo E, Janssen L, Sin O, Hogewerf W, Koster M, Harkema L, Youssef SA, Beschorner N, Wolters AH, Bakker B, Becker L, Garrett L, Marschall S, Hoelter SM, Wurst W, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Thathiah A, Foijer F, van de Sluis B, van Deursen J, Jucker M, de Bruin A, Nollen EA. Stroo E, et al. Among authors: beschorner n. Life Sci Alliance. 2023 May 2;6(7):e202201730. doi: 10.26508/lsa.202201730. Print 2023 Jul. Life Sci Alliance. 2023. PMID: 37130781 Free PMC article.
Pretargeted imaging beyond the blood-brain barrier.
Shalgunov V, Lopes van den Broek S, Vang Andersen I, García Vázquez R, Raval NR, Palner M, Mori Y, Schäfer G, Herrmann B, Mikula H, Beschorner N, Nedergaard M, Syvänen S, Barz M, Moos Knudsen G, Battisti UM, Herth MM. Shalgunov V, et al. Among authors: beschorner n. RSC Med Chem. 2022 Dec 2;14(3):444-453. doi: 10.1039/d2md00360k. eCollection 2023 Mar 22. RSC Med Chem. 2022. PMID: 36970152 Free PMC article.
Precise excision of HTLV-1 provirus with a designer-recombinase.
Rojo-Romanos T, Karpinski J, Millen S, Beschorner N, Simon F, Paszkowski-Rogacz M, Lansing F, Schneider PM, Sonntag J, Hauber J, Thoma-Kress AK, Buchholz F. Rojo-Romanos T, et al. Among authors: beschorner n. Mol Ther. 2023 Jul 5;31(7):2266-2285. doi: 10.1016/j.ymthe.2023.03.014. Epub 2023 Mar 17. Mol Ther. 2023. PMID: 36934299 Free article.
16 results