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Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates.
Zwick V, Nurisso A, Simões-Pires C, Bouchet S, Martinet N, Lehotzky A, Ovadi J, Cuendet M, Blanquart C, Bertrand P. Zwick V, et al. Among authors: bertrand p. Bioorg Med Chem Lett. 2016 Jan 1;26(1):154-9. doi: 10.1016/j.bmcl.2015.11.011. Epub 2015 Nov 11. Bioorg Med Chem Lett. 2016. PMID: 26611919
HDAC inhibitors: a 2013-2017 patent survey.
Faria Freitas M, Cuendet M, Bertrand P. Faria Freitas M, et al. Among authors: bertrand p. Expert Opin Ther Pat. 2018 Apr 19:1-17. doi: 10.1080/13543776.2018.1459568. Online ahead of print. Expert Opin Ther Pat. 2018. PMID: 29671355
Synthesis of rigid trichostatin A analogs as HDAC inhibitors.
Charrier C, Bertrand P, Gesson JP, Roche J. Charrier C, et al. Among authors: bertrand p. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5339-44. doi: 10.1016/j.bmcl.2006.07.080. Epub 2006 Aug 14. Bioorg Med Chem Lett. 2006. PMID: 16904890
Inside HDAC with HDAC inhibitors.
Bertrand P. Bertrand P. Eur J Med Chem. 2010 Jun;45(6):2095-116. doi: 10.1016/j.ejmech.2010.02.030. Epub 2010 Feb 14. Eur J Med Chem. 2010. PMID: 20223566 Review.
960 results