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Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.
Yeon M, Bertolini I, Agarwal E, Ghosh JC, Tang HY, Speicher DW, Keeney F, Sossey-Alaoui K, Pluskota E, Bialkowska K, Plow EF, Languino LR, Skordalakes E, Caino MC, Altieri DC. Yeon M, et al. Among authors: bertolini i. J Biol Chem. 2023 Jun;299(6):104774. doi: 10.1016/j.jbc.2023.104774. Epub 2023 May 2. J Biol Chem. 2023. PMID: 37142218 Free PMC article.
Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.
Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, Locatelli M, Bryant KG, Ghosh JC, Lisanti S, Ku B, Bosari S, Languino LR, Speicher DW, Altieri DC. Chae YC, et al. Among authors: bertolini i. Cancer Cell. 2016 Aug 8;30(2):257-272. doi: 10.1016/j.ccell.2016.07.004. Cancer Cell. 2016. PMID: 27505672 Free PMC article.
IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α-regulated pseudohypoxic state.
Wang Y, Agarwal E, Bertolini I, Ghosh JC, Seo JH, Altieri DC. Wang Y, et al. Among authors: bertolini i. FASEB J. 2019 Dec;33(12):13398-13411. doi: 10.1096/fj.201901366R. Epub 2019 Sep 17. FASEB J. 2019. PMID: 31530011 Free PMC article.
This pathway may reprogram mitochondrial dynamics to differentially adjust energy production or promote tumor cell invasion in response to microenvironment conditions.-Wang, Y., Agarwal, E., Bertolini, I., Ghosh, J. C., Seo, J. H., Altieri, D. C. IDH2 reprograms mit …
This pathway may reprogram mitochondrial dynamics to differentially adjust energy production or promote tumor cell invasion in response to m …
Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability.
Ghosh JC, Perego M, Agarwal E, Bertolini I, Wang Y, Goldman AR, Tang HY, Kossenkov AV, Landis CJ, Languino LR, Plow EF, Morotti A, Ottobrini L, Locatelli M, Speicher DW, Caino MC, Cassel J, Salvino JM, Robert ME, Vaira V, Altieri DC. Ghosh JC, et al. Among authors: bertolini i. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2115624119. doi: 10.1073/pnas.2115624119. Proc Natl Acad Sci U S A. 2022. PMID: 35177476 Free PMC article.
32 results