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Platelets Fuel the Inflammasome Activation of Innate Immune Cells.
Rolfes V, Ribeiro LS, Hawwari I, Böttcher L, Rosero N, Maasewerd S, Santos MLS, Próchnicki T, Silva CMS, Wanderley CWS, Rothe M, Schmidt SV, Stunden HJ, Bertheloot D, Rivas MN, Fontes CJ, Carvalho LH, Cunha FQ, Latz E, Arditi M, Franklin BS. Rolfes V, et al. Among authors: bertheloot d. Cell Rep. 2020 May 12;31(6):107615. doi: 10.1016/j.celrep.2020.107615. Cell Rep. 2020. PMID: 32402278 Free PMC article.
Innate immune receptors for nucleic acids.
Stutz A, Bertheloot D, Latz E. Stutz A, et al. Among authors: bertheloot d. Methods Mol Biol. 2011;748:69-82. doi: 10.1007/978-1-61779-139-0_5. Methods Mol Biol. 2011. PMID: 21701967
Transcriptome assessment reveals a dominant role for TLR4 in the activation of human monocytes by the alarmin MRP8.
Fassl SK, Austermann J, Papantonopoulou O, Riemenschneider M, Xue J, Bertheloot D, Freise N, Spiekermann C, Witten A, Viemann D, Kirschnek S, Stoll M, Latz E, Schultze JL, Roth J, Vogl T. Fassl SK, et al. Among authors: bertheloot d. J Immunol. 2015 Jan 15;194(2):575-83. doi: 10.4049/jimmunol.1401085. Epub 2014 Dec 10. J Immunol. 2015. PMID: 25505274 Clinical Trial.
RAGE Enhances TLR Responses through Binding and Internalization of RNA.
Bertheloot D, Naumovski AL, Langhoff P, Horvath GL, Jin T, Xiao TS, Garbi N, Agrawal S, Kolbeck R, Latz E. Bertheloot D, et al. J Immunol. 2016 Nov 15;197(10):4118-4126. doi: 10.4049/jimmunol.1502169. Epub 2016 Oct 19. J Immunol. 2016. PMID: 27798148 Free PMC article.
Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo.
Bertheloot D, Wanderley CW, Schneider AH, Schiffelers LD, Wuerth JD, Tödtmann JM, Maasewerd S, Hawwari I, Duthie F, Rohland C, Ribeiro LS, Jenster LM, Rosero N, Tesfamariam YM, Cunha FQ, Schmidt FI, Franklin BS. Bertheloot D, et al. EMBO Mol Med. 2022 Jun 8;14(6):e15415. doi: 10.15252/emmm.202115415. Epub 2022 Apr 19. EMBO Mol Med. 2022. PMID: 35438238 Free PMC article.
RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.
Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E. Sirois CM, et al. Among authors: bertheloot d. J Exp Med. 2013 Oct 21;210(11):2447-63. doi: 10.1084/jem.20120201. Epub 2013 Sep 30. J Exp Med. 2013. PMID: 24081950 Free PMC article.
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