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Small-molecule WNK inhibition regulates cardiovascular and renal function.
Nat Chem Biol. 2016 Nov;12(11):896-898. doi: 10.1038/nchembio.2168. Epub 2016 Sep 5.
Nat Chem Biol. 2016.
PMID: 27595330
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Johannessen L, Sundberg TB, O'Connell DJ, Kolde R, Berstler J, Billings KJ, Khor B, Seashore-Ludlow B, Fassl A, Russell CN, Latorre IJ, Jiang B, Graham DB, Perez JR, Sicinski P, Phillips AJ, Schreiber SL, Gray NS, Shamji AF, Xavier RJ.
Johannessen L, et al. Among authors: berstler j.
Nat Chem Biol. 2017 Oct;13(10):1102-1108. doi: 10.1038/nchembio.2458. Epub 2017 Aug 14.
Nat Chem Biol. 2017.
PMID: 28805801
Free PMC article.
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RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.
Fang L, Ford-Roshon D, Russo M, O'Brien C, Xiong X, Gurjao C, Grandclaudon M, Raghavan S, Corsello SM, Carr SA, Udeshi ND, Berstler J, Sicinska E, Ng K, Giannakis M.
Fang L, et al. Among authors: berstler j.
Nat Commun. 2022 Jun 8;13(1):3181. doi: 10.1038/s41467-022-30794-7.
Nat Commun. 2022.
PMID: 35676246
Free PMC article.
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A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives.
Li Y, Wei L, Meinsohn MC, Suliman R, Chauvin M, Berstler J, Hartland K, Jensen MM, Sicher NA, Nagykery N, Donahoe PK, Pepin D.
Li Y, et al. Among authors: berstler j.
Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2122512119. doi: 10.1073/pnas.2122512119. Epub 2022 Apr 5.
Proc Natl Acad Sci U S A. 2022.
PMID: 35380904
Free PMC article.
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High-Throughput Assay to Screen Small Molecules for Their Ability to Prevent Sickling of Red Blood Cells.
Nakagawa A, Cooper MK, Kost-Alimova M, Berstler J, Yu B, Berra L, Klings ES, Huang MS, Heeney MM, Bloch DB, Zapol WM.
Nakagawa A, et al. Among authors: berstler j.
ACS Omega. 2022 Apr 15;7(16):14009-14016. doi: 10.1021/acsomega.2c00541. eCollection 2022 Apr 26.
ACS Omega. 2022.
PMID: 35559170
Free PMC article.
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Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations.
Chandrasekaran SN, Cimini BA, Goodale A, Miller L, Kost-Alimova M, Jamali N, Doench JG, Fritchman B, Skepner A, Melanson M, Kalinin AA, Arevalo J, Haghighi M, Caicedo JC, Kuhn D, Hernandez D, Berstler J, Shafqat-Abbasi H, Root DE, Swalley SE, Garg S, Singh S, Carpenter AE.
Chandrasekaran SN, et al. Among authors: berstler j.
Nat Methods. 2024 Apr 9. doi: 10.1038/s41592-024-02241-6. Online ahead of print.
Nat Methods. 2024.
PMID: 38594452
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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Babbe H, Sundberg TB, Tichenor M, Seierstad M, Bacani G, Berstler J, Chai W, Chang L, Chung M, Coe K, Collins B, Finley M, Guletsky A, Lemke CT, Mak PA, Mathur A, Mercado-Marin EV, Metkar S, Raymond DD, Rives ML, Rizzolio M, Shaffer PL, Smith R, Smith J, Steele R, Steffens H, Suarez J, Tian G, Majewski N, Volak LP, Wei J, Desai PT, Ong LL, Koudriakova T, Goldberg SD, Hirst G, Kaushik VK, Ort T, Seth N, Graham DB, Plevy S, Venable JD, Xavier RJ, Towne JE.
Babbe H, et al. Among authors: berstler j.
Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2307086120. doi: 10.1073/pnas.2307086120. Epub 2023 Dec 26.
Proc Natl Acad Sci U S A. 2024.
PMID: 38147543
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