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Bioreporters for direct mode of action-informed screening of antibiotic producer strains.
Wex KW, Saur JS, Handel F, Ortlieb N, Mokeev V, Kulik A, Niedermeyer THJ, Mast Y, Grond S, Berscheid A, Brötz-Oesterhelt H. Wex KW, et al. Among authors: berscheid a. Cell Chem Biol. 2021 Aug 19;28(8):1242-1252.e4. doi: 10.1016/j.chembiol.2021.02.022. Epub 2021 Mar 23. Cell Chem Biol. 2021. PMID: 33761329 Free article.
Cyclic Cystine-Bridged Peptides from the Marine Sponge Clathria basilana Induce Apoptosis in Tumor Cells and Depolarize the Bacterial Cytoplasmic Membrane.
Mokhlesi A, Stuhldreier F, Wex KW, Berscheid A, Hartmann R, Rehberg N, Sureechatchaiyan P, Chaidir C, Kassack MU, Kalscheuer R, Brötz-Oesterhelt H, Wesselborg S, Stork B, Daletos G, Proksch P. Mokhlesi A, et al. Among authors: berscheid a. J Nat Prod. 2017 Nov 22;80(11):2941-2952. doi: 10.1021/acs.jnatprod.7b00477. Epub 2017 Nov 2. J Nat Prod. 2017. PMID: 29094598
Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability.
Schilling NA, Berscheid A, Schumacher J, Saur JS, Konnerth MC, Wirtz SN, Beltrán-Beleña JM, Zipperer A, Krismer B, Peschel A, Kalbacher H, Brötz-Oesterhelt H, Steinem C, Grond S. Schilling NA, et al. Among authors: berscheid a. Angew Chem Int Ed Engl. 2019 Jul 1;58(27):9234-9238. doi: 10.1002/anie.201901589. Epub 2019 May 27. Angew Chem Int Ed Engl. 2019. PMID: 31059155 Free PMC article.
High Plasticity of the Amicetin Biosynthetic Pathway in Streptomyces sp. SHP 22-7 Led to the Discovery of Streptcytosine P and Cytosaminomycins F and G and Facilitated the Production of 12F-Plicacetin.
Aryal N, Chen J, Bhattarai K, Hennrich O, Handayani I, Kramer M, Straetener J, Wommer T, Berscheid A, Peter S, Reiling N, Brötz-Oesterhelt H, Geibel C, Lämmerhofer M, Mast Y, Gross H. Aryal N, et al. Among authors: berscheid a. J Nat Prod. 2022 Mar 25;85(3):530-539. doi: 10.1021/acs.jnatprod.1c01051. Epub 2022 Mar 9. J Nat Prod. 2022. PMID: 35263115
Nostotrebin 6 Related Cyclopentenediones and δ-Lactones with Broad Activity Spectrum Isolated from the Cultivation Medium of the Cyanobacterium Nostoc sp. CBT1153.
Kossack R, Breinlinger S, Nguyen T, Moschny J, Straetener J, Berscheid A, Brötz-Oesterhelt H, Enke H, Schirmeister T, Niedermeyer THJ. Kossack R, et al. Among authors: berscheid a. J Nat Prod. 2020 Feb 28;83(2):392-400. doi: 10.1021/acs.jnatprod.9b00885. Epub 2020 Jan 24. J Nat Prod. 2020. PMID: 31977209
Human commensals producing a novel antibiotic impair pathogen colonization.
Zipperer A, Konnerth MC, Laux C, Berscheid A, Janek D, Weidenmaier C, Burian M, Schilling NA, Slavetinsky C, Marschal M, Willmann M, Kalbacher H, Schittek B, Brötz-Oesterhelt H, Grond S, Peschel A, Krismer B. Zipperer A, et al. Among authors: berscheid a. Nature. 2016 Jul 28;535(7613):511-6. doi: 10.1038/nature18634. Nature. 2016. PMID: 27466123
Synergetic Antimicrobial Activity and Mechanism of Clotrimazole-Linked CO-Releasing Molecules.
Mendes SS, Marques J, Mesterházy E, Straetener J, Arts M, Pissarro T, Reginold J, Berscheid A, Bornikoel J, Kluj RM, Mayer C, Oesterhelt F, Friães S, Royo B, Schneider T, Brötz-Oesterhelt H, Romão CC, Saraiva LM. Mendes SS, et al. Among authors: berscheid a. ACS Bio Med Chem Au. 2022 Aug 17;2(4):419-436. doi: 10.1021/acsbiomedchemau.2c00007. Epub 2022 Apr 8. ACS Bio Med Chem Au. 2022. PMID: 35996473 Free PMC article.
21 results