Bernardo-Seisdedos G - Search Results

1

An Epoxide Intermediate in Glycosidase Catalysis.

Sobala LF, Speciale G, Zhu S, Raich L, Sannikova N, Thompson AJ, Hakki Z, Lu D, Shamsi Kazem Abadi S, Lewis AR, Rojas-Cervellera V, Bernardo-Seisdedos G, Zhang Y, Millet O, Jiménez-Barbero J, Bennet AJ, Sollogoub M, Rovira C, Davies GJ, Williams SJ. Sobala LF, et al. ACS Cent Sci. 2020 May 27;6(5):760-770. doi: 10.1021/acscentsci.0c00111. Epub 2020 Apr 16. ACS Cent Sci. 2020. PMID: 32490192 Free PMC article.

2

Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase.

Petricevic M, Sobala LF, Fernandes PZ, Raich L, Thompson AJ, Bernardo-Seisdedos G, Millet O, Zhu S, Sollogoub M, Jiménez-Barbero J, Rovira C, Davies GJ, Williams SJ. Petricevic M, et al. J Am Chem Soc. 2017 Jan 25;139(3):1089-1097. doi: 10.1021/jacs.6b10075. Epub 2017 Jan 17. J Am Chem Soc. 2017. PMID: 27992199 Free PMC article.

3

Missense UROS mutations causing congenital erythropoietic porphyria reduce UROS homeostasis that can be rescued by proteasome inhibition.

Blouin JM, Bernardo-Seisdedos G, Sasso E, Esteve J, Ged C, Lalanne M, Sanz-Parra A, Urquiza P, de Verneuil H, Millet O, Richard E. Blouin JM, et al. Hum Mol Genet. 2017 Apr 15;26(8):1565-1576. doi: 10.1093/hmg/ddx067. Hum Mol Genet. 2017. PMID: 28334762

4

Structural basis and energy landscape for the Ca²⁺ gating and calmodulation of the Kv7.2 K⁺ channel.

Bernardo-Seisdedos G, Nuñez E, Gomis-Perez C, Malo C, Villarroel Á, Millet O. Bernardo-Seisdedos G, et al. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2395-2400. doi: 10.1073/pnas.1800235115. Epub 2018 Feb 20. Proc Natl Acad Sci U S A. 2018. PMID: 29463698 Free PMC article.

5

Structural basis of pyrrole polymerization in human porphobilinogen deaminase.

Pluta P, Roversi P, Bernardo-Seisdedos G, Rojas AL, Cooper JB, Gu S, Pickersgill RW, Millet O. Pluta P, et al. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1948-1955. doi: 10.1016/j.bbagen.2018.06.013. Epub 2018 Jun 15. Biochim Biophys Acta Gen Subj. 2018. PMID: 29908816 Free PMC article.

6

From 1,4-Disaccharide to 1,3-Glycosyl Carbasugar: Synthesis of a Bespoke Inhibitor of Family GH99 Endo-α-mannosidase.

Lu D, Zhu S, Sobala LF, Bernardo-Seisdedos G, Millet O, Zhang Y, Jiménez-Barbero J, Davies GJ, Sollogoub M. Lu D, et al. Org Lett. 2018 Dec 7;20(23):7488-7492. doi: 10.1021/acs.orglett.8b03260. Epub 2018 Nov 14. Org Lett. 2018. PMID: 30427198

7

Hereditary tyrosinemia type I-associated mutations in fumarylacetoacetate hydrolase reduce the enzyme stability and increase its aggregation rate.

Macias I, Laín A, Bernardo-Seisdedos G, Gil D, Gonzalez E, Falcon-Perez JM, Millet O. Macias I, et al. J Biol Chem. 2019 Aug 30;294(35):13051-13060. doi: 10.1074/jbc.RA119.009367. Epub 2019 Jul 12. J Biol Chem. 2019. PMID: 31300554 Free PMC article.

8

Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin-1.

Bertuzzi S, Gimeno A, Núñez-Franco R, Bernardo-Seisdedos G, Delgado S, Jiménez-Osés G, Millet O, Jiménez-Barbero J, Ardá A. Bertuzzi S, et al. Chemistry. 2020 Dec 1;26(67):15643-15653. doi: 10.1002/chem.202003212. Epub 2020 Oct 29. Chemistry. 2020. PMID: 32780906 Free PMC article.

9

Therapeutic Targeting of Fumaryl Acetoacetate Hydrolase in Hereditary Tyrosinemia Type I.

Gil-Martínez J, Macias I, Unione L, Bernardo-Seisdedos G, Lopitz-Otsoa F, Fernandez-Ramos D, Lain A, Sanz-Parra A, Mato JM, Millet O. Gil-Martínez J, et al. Int J Mol Sci. 2021 Feb 11;22(4):1789. doi: 10.3390/ijms22041789. Int J Mol Sci. 2021. PMID: 33670179 Free PMC article.

10

Cosolute modulation of protein oligomerization reactions in the homeostatic timescale.

Mateos B, Bernardo-Seisdedos G, Dietrich V, Zalba N, Ortega G, Peccati F, Jiménez-Osés G, Konrat R, Tollinger M, Millet O. Mateos B, et al. Biophys J. 2021 May 18;120(10):2067-2077. doi: 10.1016/j.bpj.2021.03.020. Epub 2021 Mar 29. Biophys J. 2021. PMID: 33794151 Free PMC article.

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