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HIF-1α is over-expressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia.
Griggio V, Vitale C, Todaro M, Riganti C, Kopecka J, Salvetti C, Bomben R, Bo MD, Magliulo D, Rossi D, Pozzato G, Bonello L, Marchetti M, Omedè P, Kodipad AA, Laurenti L, Del Poeta G, Mauro FR, Bernardi R, Zenz T, Gattei V, Gaidano G, Foà R, Massaia M, Boccadoro M, Coscia M. Griggio V, et al. Among authors: bernardi r. Haematologica. 2020 Apr;105(4):1042-1054. doi: 10.3324/haematol.2019.217430. Epub 2019 Jul 9. Haematologica. 2020. PMID: 31289209 Free PMC article.
HIF-α factors as potential therapeutic targets in leukemia.
Magliulo D, Bernardi R. Magliulo D, et al. Among authors: bernardi r. Expert Opin Ther Targets. 2018 Nov;22(11):917-928. doi: 10.1080/14728222.2018.1538357. Epub 2018 Oct 27. Expert Opin Ther Targets. 2018. PMID: 30345855 Review.
Hypoxic stress and hypoxia-inducible factors in leukemias.
Magliulo D, Bernardi R. Magliulo D, et al. Among authors: bernardi r. Front Oncol. 2022 Aug 18;12:973978. doi: 10.3389/fonc.2022.973978. eCollection 2022. Front Oncol. 2022. PMID: 36059690 Free PMC article. Review.
HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment.
Valsecchi R, Coltella N, Belloni D, Ponente M, Ten Hacken E, Scielzo C, Scarfò L, Bertilaccio MT, Brambilla P, Lenti E, Martinelli Boneschi F, Brendolan A, Ferrero E, Ferrarini M, Ghia P, Tonon G, Ponzoni M, Caligaris-Cappio F, Bernardi R. Valsecchi R, et al. Among authors: bernardi r. Blood. 2016 Apr 21;127(16):1987-97. doi: 10.1182/blood-2015-07-657056. Epub 2016 Jan 29. Blood. 2016. PMID: 26825709 Free PMC article.
A retinoic acid-dependent stroma-leukemia crosstalk promotes chronic lymphocytic leukemia progression.
Farinello D, Wozińska M, Lenti E, Genovese L, Bianchessi S, Migliori E, Sacchetti N, di Lillo A, Bertilaccio MTS, de Lalla C, Valsecchi R, Gleave SB, Lligé D, Scielzo C, Mauri L, Ciampa MG, Scarfò L, Bernardi R, Lazarevic D, Gonzalez-Farre B, Bongiovanni L, Campo E, Cerutti A, Ponzoni M, Pattini L, Caligaris-Cappio F, Ghia P, Brendolan A. Farinello D, et al. Among authors: bernardi r. Nat Commun. 2018 May 3;9(1):1787. doi: 10.1038/s41467-018-04150-7. Nat Commun. 2018. PMID: 29725010 Free PMC article.
437 results