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SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species.
Demange P, Joly E, Marcoux J, Zanon PRA, Listunov D, Rullière P, Barthes C, Noirot C, Izquierdo JB, Rozié A, Pradines K, Hee R, de Brito MV, Marcellin M, Serre RF, Bouchez O, Burlet-Schiltz O, Oliveira MCF, Ballereau S, Bernardes-Génisson V, Maraval V, Calsou P, Hacker SM, Génisson Y, Chauvin R, Britton S. Demange P, et al. Among authors: bernardes genisson v. Elife. 2022 May 10;11:e73913. doi: 10.7554/eLife.73913. Elife. 2022. PMID: 35535493 Free PMC article.
Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids.
Bossuat M, Rullière P, Preuilh N, Peixoto A, Joly E, Gomez JG, Bourkhis M, Rodriguez F, Gonçalves F, Fabing I, Gaspard H, Bernardes-Génisson V, Maraval V, Ballereau S, Chauvin R, Britton S, Génisson Y. Bossuat M, et al. Among authors: bernardes genisson v. J Med Chem. 2023 Oct 26;66(20):13918-13945. doi: 10.1021/acs.jmedchem.3c00859. Epub 2023 Oct 10. J Med Chem. 2023. PMID: 37816126
Dendritic Pyridine-Imine Copper Complexes as Metallo-Drugs.
Laurent R, Maraval V, Bernardes-Génisson V, Caminade AM. Laurent R, et al. Among authors: bernardes genisson v. Molecules. 2024 Apr 16;29(8):1800. doi: 10.3390/molecules29081800. Molecules. 2024. PMID: 38675623 Free PMC article. Review.
Pentacyanoferrate(II) complex of pyridine-4- and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities.
Carvalho EM, de Freitas Paulo T, Saquet AS, Abbadi BL, Macchi FS, Bizarro CV, de Morais Campos R, Ferreira TLA, do Nascimento NRF, Lopes LGF, Chauvin R, Sousa EHS, Bernardes-Génisson V. Carvalho EM, et al. Among authors: bernardes genisson v. J Biol Inorg Chem. 2020 Sep;25(6):887-901. doi: 10.1007/s00775-020-01805-z. Epub 2020 Jul 29. J Biol Inorg Chem. 2020. PMID: 32728907
A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity.
Carvalho EM, Ridnour LA, Júnior FSG, Cabral PHB, do Nascimento NRF, Wink DA, Franco DW, de Medeiros MJC, de Lima Pontes D, Longhinotti E, de Freitas Paulo T, Bernardes-Génisson V, Chauvin R, Sousa EHS, Lopes LGF. Carvalho EM, et al. Among authors: bernardes genisson v. J Inorg Biochem. 2020 Sep;210:111133. doi: 10.1016/j.jinorgbio.2020.111133. Epub 2020 Jun 20. J Inorg Biochem. 2020. PMID: 32619898 Free PMC article.
Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy.
Laborde J, Deraeve C, de Mesquita Vieira FG, Sournia-Saquet A, Rechignat L, Villela AD, Abbadi BL, Macchi FS, Pissinate K, Bizarro CV, Machado P, Basso LA, Pratviel G, de França Lopes LG, Sousa EHS, Bernardes-Génisson V. Laborde J, et al. J Inorg Biochem. 2018 Feb;179:71-81. doi: 10.1016/j.jinorgbio.2017.11.013. Epub 2017 Nov 21. J Inorg Biochem. 2018. PMID: 29175704
33 results