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101 results

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Page 1
Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial.
Le Lamer S, Paradis S, Rahmouni H, Chaimbault C, Michaud M, Culcasi M, Afxantidis J, Latreille M, Berna P, Berdeaux A, Pietri S, Morin D, Donazzolo Y, Abitbol JL, Pruss RM, Schaller S. Le Lamer S, et al. Among authors: berna p. J Transl Med. 2014 Feb 7;12:38. doi: 10.1186/1479-5876-12-38. J Transl Med. 2014. PMID: 24507657 Free PMC article. Clinical Trial.
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
Lorthiois E, Bernardelli P, Vergne F, Oliveira C, Mafroud AK, Proust E, Heuze L, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Wrigglesworth R, Descours A, Soulard P, Berna P. Lorthiois E, et al. Among authors: berna p. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4623-6. doi: 10.1016/j.bmcl.2004.07.011. Bioorg Med Chem Lett. 2004. PMID: 15324876
Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.
Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Royer F, Wrigglesworth R, Schellhaas J, Barvian M, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Berna P, Soulard P. Vergne F, et al. Among authors: berna p. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4607-13. doi: 10.1016/j.bmcl.2004.07.008. Bioorg Med Chem Lett. 2004. PMID: 15324874
Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives.
Vergne F, Bernardelli P, Lorthiois E, Pham N, Proust E, Oliveira C, Mafroud AK, Ducrot P, Wrigglesworth R, Berlioz-Seux F, Coleon F, Chevalier E, Moreau F, Idrissi M, Tertre A, Descours A, Berna P, Li M. Vergne F, et al. Among authors: berna p. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4615-21. doi: 10.1016/j.bmcl.2004.07.009. Bioorg Med Chem Lett. 2004. PMID: 15324875
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives.
Bernardelli P, Lorthiois E, Vergne F, Oliveira C, Mafroud AK, Proust E, Pham N, Ducrot P, Moreau F, Idrissi M, Tertre A, Bertin B, Coupe M, Chevalier E, Descours A, Berlioz-Seux F, Berna P, Li M. Bernardelli P, et al. Among authors: berna p. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4627-31. doi: 10.1016/j.bmcl.2004.07.010. Bioorg Med Chem Lett. 2004. PMID: 15324877
Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma.
Chevalier E, Lagente V, Dupont M, Fargeau H, Palazzi X, Richard V, Dassaud M, Fric M, Coupe M, Carré C, Leduc S, Bernardelli P, Vergne F, Berna P, Bertrand CP. Chevalier E, et al. Among authors: berna p. Eur Respir J. 2012 Mar;39(3):582-8. doi: 10.1183/09031936.00102610. Epub 2011 Nov 16. Eur Respir J. 2012. PMID: 22088971 Free article.
101 results