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Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation.
Martínez-Sánchez LDC, Ngo PA, Pradhan R, Becker LS, Boehringer D, Soteriou D, Kubankova M, Schweitzer C, Koch T, Thonn V, Erkert L, Stolzer I, Günther C, Becker C, Weigmann B, Klewer M, Daniel C, Amann K, Tenzer S, Atreya R, Bergo M, Brakebusch C, Watson AJM, Guck J, Fabry B, Atreya I, Neurath MF, López-Posadas R. Martínez-Sánchez LDC, et al. Among authors: bergo m. Gut. 2023 Feb;72(2):275-294. doi: 10.1136/gutjnl-2021-325520. Epub 2022 Mar 3. Gut. 2023. PMID: 35241625 Free PMC article.
Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice.
López-Posadas R, Fastancz P, Martínez-Sánchez LDC, Panteleev-Ivlev J, Thonn V, Kisseleva T, Becker LS, Schulz-Kuhnt A, Zundler S, Wirtz S, Atreya R, Carlé B, Friedrich O, Schürmann S, Waldner MJ, Neufert C, Brakebusch CH, Bergö MO, Neurath MF, Atreya I. López-Posadas R, et al. Gastroenterology. 2019 Nov;157(5):1293-1309. doi: 10.1053/j.gastro.2019.07.007. Epub 2019 Jul 11. Gastroenterology. 2019. PMID: 31302143 Free article.
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation.
López-Posadas R, Becker C, Günther C, Tenzer S, Amann K, Billmeier U, Atreya R, Fiorino G, Vetrano S, Danese S, Ekici AB, Wirtz S, Thonn V, Watson AJ, Brakebusch C, Bergö M, Neurath MF, Atreya I. López-Posadas R, et al. Among authors: bergo m. J Clin Invest. 2016 Feb;126(2):611-26. doi: 10.1172/JCI80997. Epub 2016 Jan 11. J Clin Invest. 2016. PMID: 26752649 Free PMC article.
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.
Akula MK, Ibrahim MX, Ivarsson EG, Khan OM, Kumar IT, Erlandsson M, Karlsson C, Xu X, Brisslert M, Brakebusch C, Wang D, Bokarewa M, Sayin VI, Bergo MO. Akula MK, et al. Among authors: bergo mo. Nat Commun. 2019 Sep 4;10(1):3975. doi: 10.1038/s41467-019-11606-x. Nat Commun. 2019. PMID: 31484924 Free PMC article.
Lack of RAC1 in macrophages protects against atherosclerosis.
Bandaru S, Ala C, Ekstrand M, Akula MK, Pedrelli M, Liu X, Bergström G, Håversen L, Borén J, Bergo MO, Akyürek LM. Bandaru S, et al. Among authors: bergo mo. PLoS One. 2020 Sep 17;15(9):e0239284. doi: 10.1371/journal.pone.0239284. eCollection 2020. PLoS One. 2020. PMID: 32941503 Free PMC article.
Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer.
Liu M, Sjogren AK, Karlsson C, Ibrahim MX, Andersson KM, Olofsson FJ, Wahlstrom AM, Dalin M, Yu H, Chen Z, Yang SH, Young SG, Bergo MO. Liu M, et al. Among authors: bergo mo. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6471-6. doi: 10.1073/pnas.0908396107. Epub 2010 Mar 22. Proc Natl Acad Sci U S A. 2010. PMID: 20308544 Free PMC article.
Control of the innate immune response by the mevalonate pathway.
Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D. Akula MK, et al. Among authors: bergo mo. Nat Immunol. 2016 Aug;17(8):922-9. doi: 10.1038/ni.3487. Epub 2016 Jun 6. Nat Immunol. 2016. PMID: 27270400 Free PMC article.
113 results