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The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models.
Sigaud R, Rösch L, Gatzweiler C, Benzel J, von Soosten L, Peterziel H, Selt F, Najafi S, Ayhan S, Gerloff XF, Hofmann N, Büdenbender I, Schmitt L, Foerster KI, Burhenne J, Haefeli WE, Korshunov A, Sahm F, van Tilburg CM, Jones DTW, Pfister SM, Knoerzer D, Kreider BL, Sauter M, Pajtler KW, Zuckermann M, Oehme I, Witt O, Milde T. Sigaud R, et al. Among authors: benzel j. Neuro Oncol. 2023 Mar 14;25(3):566-579. doi: 10.1093/neuonc/noac183. Neuro Oncol. 2023. PMID: 35882450 Free PMC article.
Analytical Performance Evaluation of New DESI Enhancements for Targeted Drug Quantification in Tissue Sections.
Fresnais M, Liang S, Breitkopf M, Lindner JR, Claude E, Pringle S, Levkin PA, Demir K, Benzel J, Sundheimer J, Statz B, Pajtler KW, Pfister SM, Haefeli WE, Burhenne J, Longuespée R. Fresnais M, et al. Among authors: benzel j. Pharmaceuticals (Basel). 2022 Jun 1;15(6):694. doi: 10.3390/ph15060694. Pharmaceuticals (Basel). 2022. PMID: 35745613 Free PMC article.
Important Requirements for the Selection of Internal Standards during the Development of Desorption/Ionization Assays for Drug Quantification in Biological Matrices-A Practical Example.
Fresnais M, Karabulut S, Abou Zeed Y, Ungermann J, Benzel J, Pajtler KW, Pfister SM, Haefeli WE, Burhenne J, Longuespée R. Fresnais M, et al. Among authors: benzel j. Molecules. 2022 Jan 21;27(3):690. doi: 10.3390/molecules27030690. Molecules. 2022. PMID: 35163955 Free PMC article.
Investigating the Central Nervous System Disposition of Actinomycin D: Implementation and Evaluation of Cerebral Microdialysis and Brain Tissue Measurements Supported by UPLC-MS/MS Quantification.
Benzel J, Bajraktari-Sylejmani G, Uhl P, Davis A, Nair S, Pfister SM, Haefeli WE, Weiss J, Burhenne J, Pajtler KW, Sauter M. Benzel J, et al. Pharmaceutics. 2021 Sep 17;13(9):1498. doi: 10.3390/pharmaceutics13091498. Pharmaceutics. 2021. PMID: 34575574 Free PMC article.
Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors.
Sievers P, Henneken SC, Blume C, Sill M, Schrimpf D, Stichel D, Okonechnikov K, Reuss DE, Benzel J, Maaß KK, Kool M, Sturm D, Zheng T, Ghasemi DR, Kohlhof-Meinecke P, Cruz O, Suñol M, Lavarino C, Ruf V, Boldt HB, Pagès M, Pouget C, Schweizer L, Kranendonk MEG, Akhtar N, Bunkowski S, Stadelmann C, Schüller U, Mueller WC, Dohmen H, Acker T, Harter PN, Mawrin C, Beschorner R, Brandner S, Snuderl M, Abdullaev Z, Aldape K, Gilbert MR, Armstrong TS, Ellison DW, Capper D, Ichimura K, Reifenberger G, Grundy RG, Jabado N, Krskova L, Zapotocky M, Vicha A, Varlet P, Wesseling P, Rutkowski S, Korshunov A, Wick W, Pfister SM, Jones DTW, von Deimling A, Pajtler KW, Sahm F. Sievers P, et al. Among authors: benzel j. Acta Neuropathol. 2021 Nov;142(5):827-839. doi: 10.1007/s00401-021-02356-6. Epub 2021 Aug 5. Acta Neuropathol. 2021. PMID: 34355256 Free PMC article.
Bioanalysis of selinexor in mouse plasma micro-samples utilizing UPLC-MS/MS.
Sauter M, Foerster KI, Benzel J, Pfister S, Pajtler KW, Haefeli WE, Burhenne J. Sauter M, et al. Among authors: benzel j. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jun 30;1176:122781. doi: 10.1016/j.jchromb.2021.122781. Epub 2021 May 20. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 34051651
Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive Supratentorial Ependymomas.
Zheng T, Ghasemi DR, Okonechnikov K, Korshunov A, Sill M, Maass KK, Benites Goncalves da Silva P, Ryzhova M, Gojo J, Stichel D, Arabzade A, Kupp R, Benzel J, Taya S, Adachi T, Shiraishi R, Gerber NU, Sturm D, Ecker J, Sievers P, Selt F, Chapman R, Haberler C, Figarella-Branger D, Reifenberger G, Fleischhack G, Rutkowski S, Donson AM, Ramaswamy V, Capper D, Ellison DW, Herold-Mende CC, Schüller U, Brandner S, Driever PH, Kros JM, Snuderl M, Milde T, Grundy RG, Hoshino M, Mack SC, Gilbertson RJ, Jones DTW, Kool M, von Deimling A, Pfister SM, Sahm F, Kawauchi D, Pajtler KW. Zheng T, et al. Among authors: benzel j. Cancer Discov. 2021 Sep;11(9):2230-2247. doi: 10.1158/2159-8290.CD-20-0963. Epub 2021 Apr 20. Cancer Discov. 2021. PMID: 33879448
28 results