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Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release.
Foster TL, Thompson GS, Kalverda AP, Kankanala J, Bentham M, Wetherill LF, Thompson J, Barker AM, Clarke D, Noerenberg M, Pearson AR, Rowlands DJ, Homans SW, Harris M, Foster R, Griffin S. Foster TL, et al. Among authors: bentham m. Hepatology. 2014 Feb;59(2):408-22. doi: 10.1002/hep.26685. Epub 2013 Dec 24. Hepatology. 2014. PMID: 24022996 Free PMC article.
Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy.
Shaw J, Gosain R, Kalita MM, Foster TL, Kankanala J, Mahato DR, Abas S, King BJ, Scott C, Brown E, Bentham MJ, Wetherill L, Bloy A, Samson A, Harris M, Mankouri J, Rowlands DJ, Macdonald A, Tarr AW, Fischer WB, Foster R, Griffin S. Shaw J, et al. Among authors: bentham mj. Elife. 2020 Nov 10;9:e52555. doi: 10.7554/eLife.52555. Elife. 2020. PMID: 33169665 Free PMC article.
Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza.
Scott C, Kankanala J, Foster TL, Goldhill DH, Bao P, Simmons K, Pingen M, Bentham M, Atkins E, Loundras E, Elderfield R, Claridge JK, Thompson J, Stilwell PR, Tathineni R, McKimmie CS, Targett-Adams P, Schnell JR, Cook GP, Evans S, Barclay WS, Foster R, Griffin S. Scott C, et al. Among authors: bentham m. PLoS Pathog. 2020 Aug 11;16(8):e1008716. doi: 10.1371/journal.ppat.1008716. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32780760 Free PMC article.
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